SCHEMBL3488312

SCHEMBL3488312

CCCCCCCCCCCCCCCC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 11/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
MAPT P10636 2/20 1.00
POLB P06746 1/20 1.00
GAA P10253 1/20 1.00
NFKB1 P19838 2/20 0.79
PMP22 Q01453 1/20 0.79
TSHR P16473 1/20 0.79
PGR P06401 4/20 0.76
SERPINA6 P08185 2/20 0.76
LMNA P02545 2/20 0.76
AR P10275 2/20 0.76
CHRM1 P11229 2/20 0.76
CYP3A4 P08684 2/20 0.74
NR3C2 P08235 4/20 0.70
NR3C1 P04150 3/20 0.69
CYP2C19 P33261 2/20 0.69
HSD17B10 Q99714 2/20 0.69
KMT2A Q03164 2/20 0.69
SHBG P04278 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7142712 1.00 HIF1A (1.00) HIF1ASMN1; SMN2MAPTPOLBGAA
SCHEMBL7137200 1.00 HIF1A (1.00) HIF1ASMN1; SMN2MAPTPOLBGAA
SCHEMBL141851 1.00 HIF1A (1.00) HIF1ASMN1; SMN2MAPTPOLBGAA
SCHEMBL5084679 0.99 HIF1A (0.98) HIF1ASMN1; SMN2MAPTPOLBGAA
SCHEMBL80604 0.98 HIF1A (0.95) HIF1ASMN1; SMN2MAPTPOLBGAA
SCHEMBL2679288 0.98 HIF1A (0.95) HIF1ASMN1; SMN2MAPTPOLBGAA
Hydrocortisone SCHEMBL365890 0.94 HIF1A (0.90) HIF1ASMN1; SMN2MAPTPOLBGAA
SCHEMBL10575587 0.94 HIF1A (0.88) HIF1ASMN1; SMN2MAPTPOLBGAA
SCHEMBL4696 0.94 HIF1A (0.88) HIF1ASMN1; SMN2MAPTPOLBGAA
SCHEMBL2679655 0.94 HIF1A (0.88) HIF1ASMN1; SMN2MAPTPOLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0041772-B2 FAT EMULSION CONTAINING A STEROID GREEN CROSS CORPORATION (JP) 1990-04-18 EP claimed
EP-0170642-A2 Liposomes containing steroid esters Aktiebolaget Draco (SE) 1986-02-05 EP claimed
EP-0041772-B1 FAT EMULSION CONTAINING A STEROID GREEN CROSS CORPORATION (JP) 1984-10-17 EP claimed
US-4427649-A A CORTICOSTEROID HAVING AN 11-HYDROXY GROUP AND A 21-LIPOPHILIC ESTER GROUP IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1984-01-24 US claimed
US-4340594-A Fat emulsion containing steroid THE GREEN CROSS CORPORATION (JP) 1982-07-20 US claimed
EP-0041772-A2 Fat emulsion containing a steroid GREEN CROSS CORPORATION (JP) 1981-12-16 EP claimed
US-20100080850-A1 POLYPEPTIDE LIGANDS FOR TARGETING CARTILAGE AND METHODS OF USE THEREOF ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 2010-04-01 US disclosed
US-7592009-B2 Polypeptide ligands for targeting cartilage and methods of use thereof ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2009-09-22 US disclosed
EP-2084275-A2 POLYPEPTIDE LIGANDS FOR TARGETING CARTILAGE AND METHODS OF USE THEREOF ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 2009-08-05 EP disclosed
WO-2008063291-A2 POLYPEPTIDE LIGANDS FOR TARGETING CARTILAGE AND METHODS OF USE THEREOF ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 2008-05-29 WO disclosed
US-20080118523-A1 Chimeric polypeptide comprising tissue inhibitor of matrix metalloproteinases-3 (TIMP-3) for use in treatment and prevention of arthritic and degenerative joint disorders ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2008-05-22 US disclosed
EP-0331755-B2 MEDICINE-CONTAINING FAT EMULSION OF THE TYPE PREPARED IMMEDIATELY BEFORE USE AND PROCESS FOR PREPARING MEDICINE-CONTAINING FAT EMULSION TEIJIN LTD (JP) 2003-02-05 EP disclosed
EP-0556394-B1 LYOPHILIZED PREPARATION AND PRODUCTION THEREOF NIPPON SHINYAKU CO LTD (JP) 2002-06-19 EP disclosed
US-4370349-A Process for preparing freeze-dried liposome compositions IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1983-01-25 US disclosed
US-4347234-A Medicinally useful, shaped mass of collagen resorbable in the body MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1982-08-31 US disclosed
US-4340594-A Fat emulsion containing steroid THE GREEN CROSS CORPORATION (JP) 1982-07-20 US disclosed
US-4311712-A Process for preparing freeze-dried liposome compositions IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-01-19 US disclosed
EP-0041772-A2 Fat emulsion containing a steroid GREEN CROSS CORPORATION (JP) 1981-12-16 EP disclosed
US-4291013-A Medicinally useful, shaped mass of collagen resorbable in the body MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1981-09-22 US disclosed
EP-0007714-A1 Liposomes and compositions containing them NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1980-02-06 EP disclosed