Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.71 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.71 |
| ▸ | NCOR2 | Q9Y618 | 6/20 | 0.71 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3489688 | 0.95 | HDAC6 (0.67) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3489723 | 0.92 | HDAC6 (0.63) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3490079 | 0.91 | HDAC6 (0.62) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3488136 | 0.85 | HDAC3 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL24754549 | 0.84 | HDAC6 (1.00) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3490100 | 0.83 | HDAC3 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3488996 | 0.82 | HDAC6 (0.55) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3490088 | 0.81 | HDAC3 (0.51) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3489559 | 0.81 | HDAC3 (0.54) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3488206 | 0.80 | GRIN1 (0.52) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094000-A1 | PYRAZOLE COMPOUNDS | NR3C2, MC2R, NR3C1 | HDAC6 1944/4885HDAC3 1381/4885HDAC4 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.