Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.55 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2483799 | 0.92 | DRD2 (0.61) | DRD2CTSKKCNA3JAK2JAK1 | |
| SCHEMBL3488494 | 0.90 | DRD2 (0.52) | DRD2CTSKKCNA3JAK2JAK1 | |
| SCHEMBL3488727 | 0.87 | CTSK (0.48) | DRD2CTSKKCNA3OPRM1OPRD1 | |
| SCHEMBL8187882 | 0.85 | DRD2 (0.55) | DRD2CTSKKCNA3BTKCA1 | |
| SCHEMBL1604214 | 0.85 | DRD2 (0.55) | DRD2CTSKKCNA3BTKCA1 | |
| SCHEMBL3370047 | 0.85 | CTSK (0.56) | DRD2CTSKKCNA3OPRM1OPRD1 | |
| SCHEMBL14651348 | 0.84 | DRD2 (0.62) | DRD2CTSKKCNA3JAK2JAK1 | |
| SCHEMBL12501447 | 0.84 | DRD2 (0.62) | DRD2CTSKKCNA3JAK2JAK1 | |
| SCHEMBL3489553 | 0.84 | CTSK (0.45) | DRD2CTSKKCNA3OPRM1OPRD1 | |
| SCHEMBL6582240 | 0.83 | DRD2 (0.53) | DRD2CTSKKCNA3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075973-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075973-A1 | POLO-LIKE KINASE INHIBITORS | PLK2, PLK4, PLK1 | DRD2 4823/4885CTSK 394/4885KCNA3 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.