Sugi Predict

Sugi Predict / Compounds / SCHEMBL3489081

SCHEMBL3489081

SCHEMBL3489081

CCCCCCCCN1C(=O)N(Cc2ccccc2)c2cc(Cl)cc(N3CCN(C)CC3)c2S1(=O)=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.43
▸ KDM4E B2RXH2 3/20 0.43
▸ TP53 P04637 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ LMNA P02545 1/20 0.40
▸ HTR1A P08908 4/20 0.37
▸ HTR7 P34969 4/20 0.37
▸ HTR6 P50406 4/20 0.37
▸ DRD2 P14416 3/20 0.37
▸ HTR2A P28223 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ PABPC1 P11940 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ USP2 O75604 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ RECQL P46063 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3488912 1.00 MAPT (0.43) MAPTKDM4ETP53HPGDMAPK1
SCHEMBL3488615 0.96 MAPT (0.44) MAPTKDM4ETP53HPGDMAPK1
SCHEMBL3489620 0.92 MAPT (0.46) MAPTKDM4ETP53HPGDMAPK1
SCHEMBL3489276 0.92 HTR6 (0.39) MAPTKDM4ETP53HPGDMAPK1
SCHEMBL3490206 0.89 MAPT (0.46) MAPTKDM4ETP53HPGDMAPK1
SCHEMBL3490278 0.89 MAPT (0.48) MAPTKDM4ETP53HPGDMAPK1
SCHEMBL3490134 0.88 MAPT (0.47) MAPTKDM4ETP53HPGDMAPK1
SCHEMBL3488509 0.87 MAPT (0.40) MAPTKDM4ETP53ALDH1A1MEN1
SCHEMBL3490753 0.87 MAPT (0.40) MAPTKDM4ETP53ALDH1A1MEN1
SCHEMBL3489623 0.86 MAPT (0.46) MAPTKDM4ETP53HPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100035866-A1 NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIAZIN-3ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2010-02-11 — — US claimed
US-20100035866-A1 NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIAZIN-3ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2010-02-11 — — US disclosed
US-20100035866-A1 NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIAZIN-3ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2010-02-11 — — US disclosed
US-20100035866-A1 NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIAZIN-3ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2010-02-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100035866-A1 NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIAZIN-3ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME OPRD1, HTR6, HTR1D MAPT 2158/4885KDM4E 3948/4885TP53 4577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.