Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 3/20 | 0.50 |
| ▸ | OXTR | P30559 | 1/20 | 0.50 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.49 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.49 |
| ▸ | NOTCH1 | P46531 | 3/20 | 0.48 |
| ▸ | RBPJ | Q06330 | 2/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.47 |
| ▸ | NOTCH3 | Q9UM47 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13501672 | 0.91 | CCKBR (0.63) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3486674 | 0.91 | CCKBR (0.63) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3486334 | 0.91 | CCKBR (0.63) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL13434950 | 0.82 | CCKBR (0.71) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3487085 | 0.82 | CCKBR (0.71) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3486542 | 0.81 | CCKBR (0.68) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3486941 | 0.80 | CCKBR (0.67) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3486975 | 0.80 | CCKBR (0.67) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3487371 | 0.79 | CCKBR (0.52) | CCKBRNOTCH1RBPJPSEN1PSEN2 | |
| SCHEMBL3487374 | 0.79 | CCKBR (0.52) | CCKBRNOTCH1RBPJPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069373-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF A BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069373-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF A BETA PROTEIN PRODUCTION | BACE1, APP, BACE2 | CCKBR 3027/4885OXTR 3242/4885RAMP1 1347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.