Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 16/20 | 0.54 |
| ▸ | CASP1 | P29466 | 7/20 | 0.54 |
| ▸ | CASP9 | P55211 | 6/20 | 0.54 |
| ▸ | CASP4 | P49662 | 2/20 | 0.54 |
| ▸ | CASP5 | P51878 | 2/20 | 0.54 |
| ▸ | CASP6 | P55212 | 2/20 | 0.54 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.54 |
| ▸ | CASP10 | Q92851 | 2/20 | 0.54 |
| ▸ | CASP7 | P55210 | 11/20 | 0.52 |
| ▸ | MME | P08473 | 3/20 | 0.47 |
| ▸ | ECE1 | P42892 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3491057 | 0.91 | PTPN1 (0.47) | CASP3CASP1CASP9CASP4CASP5 | |
| SCHEMBL3490826 | 0.84 | CASP3 (0.73) | CASP3CASP1CASP9CASP4CASP5 | |
| SCHEMBL9961887 | 0.83 | CASP3 (0.74) | CASP3CASP1CASP9CASP4CASP5 | |
| SCHEMBL18781744 | 0.83 | CASP3 (0.74) | CASP3CASP1CASP9CASP4CASP5 | |
| SCHEMBL18472372 | 0.83 | CASP3 (0.74) | CASP3CASP1CASP9CASP4CASP5 | |
| SCHEMBL31248471 | 0.83 | CAPN1 (0.51) | CASP3CASP1CASP9CASP7MME | |
| SCHEMBL29407562 | 0.81 | BACE1 (0.60) | — | |
| SCHEMBL20052444 | 0.81 | CASP3 (0.60) | CASP3CASP1CASP9CASP4CASP5 | |
| SCHEMBL29860263 | 0.81 | BACE1 (0.60) | — | |
| SCHEMBL31187019 | 0.81 | BACE1 (0.42) | CASP3CASP1CASP9CASP4CASP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160151403-A1 | SMALL MOLECULE MODULATORS OF P53 FAMILY SIGNALING | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2016-06-02 | — | — | US | disclosed |
| US-20100047783-A1 | SMALL MOLECULE MODULATORS OF P53 FAMILY SIGNALING | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2010-02-25 | — | — | US | disclosed |
| WO-2008011008-A1 | BIOLUMINESCENT IMAGING OF TRAIL INDUCED APOPTOSIS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008008155-A2 | SMALL MOLECULE MODULATORS OF P53 FAMILY SIGNALING | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-01-17 | — | — | WO | disclosed |