Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 10/20 | 0.73 |
| ▸ | CASP1 | P29466 | 5/20 | 0.73 |
| ▸ | CASP9 | P55211 | 5/20 | 0.73 |
| ▸ | CASP4 | P49662 | 3/20 | 0.73 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.73 |
| ▸ | CASP10 | Q92851 | 3/20 | 0.73 |
| ▸ | CASP5 | P51878 | 2/20 | 0.73 |
| ▸ | CASP6 | P55212 | 2/20 | 0.73 |
| ▸ | CASP7 | P55210 | 5/20 | 0.56 |
| ▸ | CTSB | P07858 | 5/20 | 0.53 |
| ▸ | CTSK | P43235 | 4/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31248472 | 0.87 | CASP3 (0.63) | CASP3CASP1CASP9CASP4CASP8 | |
| SCHEMBL30541131 | 0.85 | CASP3 (0.61) | CASP3CASP1CASP9CASP4CASP8 | |
| SCHEMBL28399571 | 0.85 | CASP3 (0.70) | CASP3CASP1CASP9CASP4CASP8 | |
| SCHEMBL3490062 | 0.84 | CASP3 (0.54) | CASP3CASP1CASP9CASP4CASP8 | |
| SCHEMBL3489141 | 0.84 | CASP1 (0.53) | CASP3CASP1CASP9CASP4CASP8 | |
| SCHEMBL3317466 | 0.84 | CASP3 (0.62) | CASP3CASP1CASP9CASP4CASP8 | |
| SCHEMBL29362585 | 0.83 | CASP3 (0.76) | CASP3CASP1CASP9CASP4CASP8 | |
| SCHEMBL30744051 | 0.83 | CASP3 (0.64) | CASP3CASP1CASP9CASP4CASP8 | |
| SCHEMBL2038060 | 0.83 | CASP3 (0.63) | CASP3CASP1CASP9CASP4CASP8 | |
| SCHEMBL3489108 | 0.82 | CASP3 (0.52) | CASP3CASP1CASP9CASP4CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079408-A1 | A ZEBRAFISH BASED SCREEN FOR AGENTS WITH ABILITY TO PREVENT CELL DEATH | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2008-07-03 | — | — | WO | claimed |
| US-20160151403-A1 | SMALL MOLECULE MODULATORS OF P53 FAMILY SIGNALING | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2016-06-02 | — | — | US | disclosed |
| US-20100047783-A1 | SMALL MOLECULE MODULATORS OF P53 FAMILY SIGNALING | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2010-02-25 | — | — | US | disclosed |
| WO-2008079408-A1 | A ZEBRAFISH BASED SCREEN FOR AGENTS WITH ABILITY TO PREVENT CELL DEATH | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008008155-A2 | SMALL MOLECULE MODULATORS OF P53 FAMILY SIGNALING | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-01-17 | — | — | WO | disclosed |
| US-20070048726-A1 | Methods and Compositions for the Control of Molecular-Based Cell Death During Preservation of Cells, Tissues or Organs in a Gel-Like State | BIOLIFE SOLUTIONS, INC. (US) | 2007-03-01 | — | — | US | disclosed |
| US-6921633-B2 | Methods and compositions for the preservation of cells, tissues or organs in the vitreous state | BIOLIFE SOLUTIONS INCORPORATED (US) | 2005-07-26 | — | — | US | disclosed |
| WO-2004046308-A2 | METHODS AND COMPOSITIONS FOR THE PRESERVATION OF CELLS, TISSUES OR ORGANS IN THE VITREOUS STATE | BIOLIFE SOLUTIONS, INC. (US) | 2004-06-03 | — | — | WO | disclosed |
| US-20040096813-A1 | Methods and compositions for the preservation of cells, tissues or organs in the vitreous state | BIOLIFE SOLUTIONS, INC. | 2004-05-20 | — | — | US | disclosed |