Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.51 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 2/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3491981 | 0.87 | ROCK2 (0.48) | CDC7CDK2CCNE1DBF4ROCK1 | |
| SCHEMBL3491934 | 0.81 | GSK3B (0.58) | CDC7CDK2CCNE1DBF4ROCK1 | |
| SCHEMBL2358127 | 0.80 | MAP4K4 (0.51) | CDC7CDK2CCNE1DBF4ROCK1 | |
| SCHEMBL2355622 | 0.78 | AURKB (0.52) | CDC7CDK2CCNE1DBF4ROCK1 | |
| SCHEMBL5112553 | 0.75 | IKBKB (0.47) | CDK2ROCK1NUDT1CCNKCDK12 | |
| SCHEMBL2356243 | 0.75 | CIT (0.47) | ROCK1NUDT1CCNKCDK12DYRK1A | |
| SCHEMBL2356502 | 0.75 | ROCK1 (0.48) | CDC7CDK2CCNE1DBF4ROCK1 | |
| SCHEMBL2357112 | 0.73 | NUDT1 (0.51) | CDC7CDK2CCNE1DBF4ROCK1 | |
| Cyclopentane SCHEMBL2358084 | 0.72 | CCNK (0.48) | ROCK1NUDT1CCNKCDK12DYRK1A | |
| SCHEMBL2358817 | 0.72 | JAK2 (0.46) | CDK2ROCK1ROCK2GSK3BPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492378-B2 | GSK-3β inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-07-23 | — | — | US | disclosed |
| US-20100069381-A1 | GSK-3BETAINHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069381-A1 | GSK-3BETAINHIBITOR | GSK3B, GSK3A, GSKIP | CDC7 1097/4885CDK2 323/4885CCNE1 2505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.