Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.71 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.66 |
| ▸ | ACHE | P22303 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.61 |
| ▸ | BCHE | P06276 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10385903 | 0.98 | CCR3 (0.69) | CCR3CXCR4ACHEALDH1A1SIGMAR1 | |
| SCHEMBL8545766 | 0.89 | CYP2D6 (0.68) | CCR3CXCR4ACHEALDH1A1SIGMAR1 | |
| SCHEMBL5968994 | 0.89 | CYP2D6 (0.68) | CCR3CXCR4ACHEALDH1A1SIGMAR1 | |
| SCHEMBL1386235 | 0.89 | CYP2D6 (0.68) | CCR3CXCR4ACHEALDH1A1SIGMAR1 | |
| SCHEMBL368874 | 0.86 | CCR3 (0.67) | CCR3CXCR4ACHEALDH1A1BCHE | |
| Oxalic Acid SCHEMBL10461399 | 0.84 | CYP2D6 (0.66) | CCR3CXCR4ACHEALDH1A1BCHE | |
| SCHEMBL5640368 | 0.83 | CYP2D6 (0.65) | CCR3ALDH1A1SIGMAR1DRD4 | |
| SCHEMBL2004615 | 0.83 | CCR3 (1.00) | CCR3ACHEALDH1A1SIGMAR1KDM4E | |
| SCHEMBL4433102 | 0.83 | CCR3 (0.73) | CCR3CXCR4ACHEALDH1A1SIGMAR1 | |
| SCHEMBL15140944 | 0.83 | CCR3 (0.73) | CCR3CXCR4ACHEALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 249 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117924153-A | Preparation method of key intermediate of donepezil bulk drug | 山东盛安贝新材料有限公司南京分公司 | 2024-04-26 | — | — | CN | claimed |
| CN-111499559-B | Method for synthesizing donepezil in water | 南京理工大学 | 2022-03-15 | — | — | CN | claimed |
| CN-113979922-A | Preparation method of N-benzylpiperidine-4-formaldehyde and N-benzylpiperidine-4-methanol | 新发药业有限公司 | 2022-01-28 | — | — | CN | claimed |
| CN-111499559-A | Method for synthesizing donepezil in water | 南京理工大学 | 2020-08-07 | — | — | CN | claimed |
| CN-107903204-B | Synthesis method of donepezil | 郑州大学 | 2020-07-03 | — | — | CN | claimed |
| WO-2012038966-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL INTERMEDIATE | TYCHE INDUSTRIES LTD. (IN) | 2012-03-29 | — | — | WO | claimed |
| EP-4606803-A1 | KRAS G12D DEGRADATION AGENT, AND PREPARATION METHOD AND USE THEREFOR | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. (CN) | 2025-08-27 | — | — | EP | disclosed |
| US-12251370-B2 | Small molecule inhibitors of the BfrB:Bfd interaction | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2025-03-18 | — | — | US | disclosed |
| CN-118930415-A | Rare earth catalytic ketone alpha-alkylation method | 复旦大学 | 2024-11-12 | — | — | CN | disclosed |
| CN-117924153-A | Preparation method of key intermediate of donepezil bulk drug | 山东盛安贝新材料有限公司南京分公司 | 2024-04-26 | — | — | CN | disclosed |
| WO-2024083258-A1 | KRAS G12C DEGRADATION AGENT, AND PREPARATION METHOD AND USE THEREFOR | 上海领泰生物医药科技有限公司 | 2024-04-25 | — | — | WO | disclosed |
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |
| EP-3440087-B1 | THIAZOLOPYRIDINE DERIVATIVES AS GPR119 AGONISTS | MANKIND PHARMA LTD (IN) | 2022-08-10 | — | — | EP | disclosed |
| EP-0501322-A1 | 3-Piperidinylmethylcarboxylate substituted indoles | GLAXO GROUP LIMITED (GB) | 1992-09-02 | — | — | EP | disclosed |
| US-5116846-A | N-ARALKYL PIPERIDINE DERIVATIVES AS PSYCHOTROPIC DRUGS | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0449186-A2 | N-aralkyl piperidine derivatives as psychotropic drugs | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-10-02 | — | — | EP | disclosed |
| EP-0449187-A2 | Piperidin ether derivatives as psychotropic drugs or plant fungicides | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-10-02 | — | — | EP | disclosed |
| US-4647565-A | 2-(2-quinazolinylaminoalkoxymethyl)-1,4-dihydropyridine derivatives as cardiovascular agents | PFIZER INC. (US) | 1987-03-03 | — | — | US | disclosed |
| EP-0168151-A1 | Dihydropyridine cardiovascular agents | Pfizer Limited (GB) | 1986-01-15 | — | — | EP | disclosed |
| US-4246262-A | ANTIBIOTICS | LEO PHARMACEUTICAL PRODUCTS, LTD. A/S (DK) | 1981-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12251370-B2 | Small molecule inhibitors of the BfrB:Bfd interaction | BLVRB, TFPI, ETFB | CCR3 4523/4885CXCR4 3604/4885ACHE 4279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.