Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | PRKACG | P22612 | 2/20 | 0.53 |
| ▸ | PRKACB | P22694 | 2/20 | 0.53 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.53 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.53 |
| ▸ | AKT2 | P31751 | 11/20 | 0.52 |
| ▸ | AKT1 | P31749 | 7/20 | 0.52 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3491258 | 0.88 | KIT (0.52) | KITROCK2PRKACAPRKACGPRKACB | |
| SCHEMBL3493149 | 0.85 | ROCK2 (0.51) | KITROCK2PRKACAPRKACGPRKACB | |
| SCHEMBL3492127 | 0.83 | AKT2 (0.53) | KITROCK2AKT2AKT1AKT3 | |
| SCHEMBL3492620 | 0.83 | AKT2 (0.49) | KITROCK2PRKACAPRKACGPRKACB | |
| SCHEMBL3492843 | 0.83 | AKT2 (0.49) | KITROCK2PRKACAPRKACGPRKACB | |
| SCHEMBL2778598 | 0.82 | AKT1 (0.63) | KITROCK2AKT2AKT1AKT3 | |
| SCHEMBL3494126 | 0.81 | AKT2 (0.55) | KITROCK2AKT2AKT1AKT3 | |
| SCHEMBL3493470 | 0.81 | AKT2 (0.49) | KITROCK2PRKACAPRKACGPRKACB | |
| SCHEMBL2780797 | 0.76 | AKT2 (0.67) | ROCK2AKT2AKT1AKT3KCNH2 | |
| SCHEMBL10156821 | 0.74 | JAK3 (0.59) | KITROCK2AKT2AKT1AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120798-A1 | SUBSTITUTED PIPERIDINES CONTAINING A HETEROARYLAMIDE OR HETEROARYLPHENYL MOIETY | ASTEX THERAPEUTICS LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120798-A1 | SUBSTITUTED PIPERIDINES CONTAINING A HETEROARYLAMIDE OR HETEROARYLPHENYL MOIETY | ASTEX THERAPEUTICS LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| US-20100120798-A1 | SUBSTITUTED PIPERIDINES CONTAINING A HETEROARYLAMIDE OR HETEROARYLPHENYL MOIETY | ASTEX THERAPEUTICS LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
| EP-2125820-A1 | SUBSTITUTED PIPERIDINES CONTAINING A HETEROARYLAMIDE OR HETEROARYLPHENYL MOIETY | Astex Therapeutics Limited (GB) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075110-A1 | SUBSTITUTED PIPERIDINES CONTAINING A HETEROARYLAMIDE OR HETEROARYLPHENYL MOIETY | ASTEX THERAPEUTICS LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008075110-A1 | SUBSTITUTED PIPERIDINES CONTAINING A HETEROARYLAMIDE OR HETEROARYLPHENYL MOIETY | ASTEX THERAPEUTICS LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120798-A1 | SUBSTITUTED PIPERIDINES CONTAINING A HETEROARYLAMIDE OR HETEROARYLPHENYL MOIETY | GRK2, GNAO1, PTGER1 | KIT 1421/4885ROCK2 83/4885PRKACA 595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.