Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.59 |
| ▸ | PDE9A | O76083 | 1/20 | 0.59 |
| ▸ | PDE1A | P54750 | 1/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.59 |
| ▸ | PNP | P00491 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | YTHDF3 | Q7Z739 | 2/20 | 0.39 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.39 |
| ▸ | YTHDF1 | Q9BYJ9 | 2/20 | 0.39 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3494823 | 0.82 | PDE5A (0.71) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL6372391 | 0.81 | PDE5A (0.62) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL6365929 | 0.78 | PDE5A (0.53) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL6372415 | 0.76 | PDE5A (0.52) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL6370997 | 0.70 | PDE9A (0.55) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL6367840 | 0.70 | MAPT (0.39) | PDE9APDE1APDE1BPDE1CPNP | |
| SCHEMBL6367545 | 0.69 | PDE9A (0.53) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL6366773 | 0.69 | PDE9A (0.51) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL401142 | 0.68 | PDE5A (0.64) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL7043355 | 0.68 | PDE5A (0.64) | PDE5APDE9APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113484-A1 | TREATING AGENT OF UROPATHY | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2010-05-06 | — | — | US | disclosed |
| EP-2123301-A1 | THERAPEUTIC AGENT FOR URINARY TRACT DISEASE | ASKA Pharmaceutical Co., Ltd. (JP) | 2009-11-25 | — | — | EP | disclosed |
| US-6967204-B2 | Treatment of insulin resistance syndrome and type 2 diabetes with PDE9 inhibitors | PFIZER INC (US) | 2005-11-22 | — | — | US | disclosed |
| US-20050070557-A1 | Treatment of insulin resistance syndrome and type 2 diabetes with PDE9 inhibitors | PFIZER INC | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113484-A1 | TREATING AGENT OF UROPATHY | BPHL, PDE12, UROD | PDE5A 14/4885PDE9A 6/4885PDE1A 44/4885 |
| US-20050070557-A1 | Treatment of insulin resistance syndrome and type 2 diabetes with PDE9 inhibitors | GPR119, PDE2A, PDE9A | PDE5A 4/4885PDE9A 3/4885PDE1A 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.