Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.64 |
| ▸ | PDE9A | O76083 | 1/20 | 0.64 |
| ▸ | PDE1A | P54750 | 1/20 | 0.64 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.64 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.64 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.43 |
| ▸ | CDK2 | P24941 | 7/20 | 0.43 |
| ▸ | CDK4 | P11802 | 5/20 | 0.41 |
| ▸ | CCND1 | P24385 | 5/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.41 |
| ▸ | CDK1 | P06493 | 4/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3494823 | 0.75 | PDE5A (0.71) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL6372391 | 0.71 | PDE5A (0.62) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL3492113 | 0.68 | PDE5A (0.59) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL401142 | 0.68 | PDE5A (0.64) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL38205 | 0.67 | PDE5A (0.64) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL8620381 | 0.66 | ALDH1A1 (0.58) | POLB | |
| SCHEMBL2110230 | 0.66 | PDE9A (0.57) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL6365929 | 0.66 | PDE5A (0.53) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL941211 | 0.65 | PDE5A (0.64) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL2769751 | 0.65 | CDK4 (0.51) | PDE5APDE9APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030195205-A1 | PDE9 inhibitors for treating cardiovascular disorders | PFIZER INC. | 2003-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195205-A1 | PDE9 inhibitors for treating cardiovascular disorders | PDE9A, PDE2A, PDE3A | PDE5A 6/4885PDE9A 1/4885PDE1A 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.