Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | HCK | P08631 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3497878 | 0.86 | — | — | |
| SCHEMBL532457 | 0.78 | BRD4 (0.37) | HTR6BUB1AKT1BRD4CREBBP | |
| SCHEMBL26683889 | 0.62 | BUB1 (0.38) | HTR6BUB1AKT1PIK3CDABL1 | |
| SCHEMBL3237691 | 0.61 | L3MBTL1 (0.44) | HTR6BUB1AKT1ACHEBRD4 | |
| SCHEMBL29507077 | 0.61 | L3MBTL1 (0.44) | HTR6BUB1AKT1ACHEBRD4 | |
| SCHEMBL24549029 | 0.61 | USP30 (0.40) | HTR6BUB1AKT1ACLYPIK3CD | |
| SCHEMBL3339983 | 0.61 | PIK3CA (0.38) | HTR6BUB1AKT1BRD4ACLY | |
| SCHEMBL24539514 | 0.61 | HSP90AA1 (0.39) | HTR6BUB1AKT1PIK3CDABL1 | |
| SCHEMBL20789959 | 0.61 | L3MBTL1 (0.42) | HTR6BUB1AKT1BRD4CREBBP | |
| SCHEMBL23042963 | 0.61 | BUB1 (0.37) | HTR6BUB1AKT1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851606-B2 | Negatively charged minor groove binders | ELITECH HOLDING B.V. (NL) | 2010-12-14 | — | — | US | disclosed |
| US-20100137614-A1 | NEGATIVELY CHARGED MINOR GROOVE BINDERS | EPOCH BIOSCIENCES, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-7582739-B2 | Negatively charged minor groove binders | EPOCH BIOSCIENCES, INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-20050187383-A1 | Negatively charged minor groove binders | LUKHTANOV, EUGENE | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187383-A1 | Negatively charged minor groove binders | PCNA, NCL, HNRNPH3 | HTR6 3933/4885BUB1 3973/4885AKT1 4865/4885 |
| US-20100137614-A1 | NEGATIVELY CHARGED MINOR GROOVE BINDERS | PCNA, NCL, HNRNPH3 | HTR6 3933/4885BUB1 3973/4885AKT1 4865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.