Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | P4HB | P07237 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | PRNP | P04156 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | NR2E3 | Q9Y5X4 | 2/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ESRRB | O95718 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESRRA | P11474 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26999154 | 0.89 | RXFP1 (0.54) | RXFP1ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL4023007 | 0.85 | RXFP1 (0.48) | RXFP1ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL16098115 | 0.83 | POLB (0.51) | RXFP1MAPTLMNAKMT2AGAA | |
| SCHEMBL13774334 | 0.83 | RXFP1 (0.61) | RXFP1ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL30064742 | 0.83 | RXFP1 (0.61) | RXFP1ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL9610043 | 0.81 | RXFP1 (0.60) | RXFP1ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL1256551 | 0.80 | ACHE (0.61) | LMNADHODHKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL3625999 | 0.80 | DHODH (0.62) | ALDH1A1MAPTLMNAKMT2AGAA | |
| SCHEMBL18285493 | 0.80 | RXFP1 (0.58) | RXFP1ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL10610649 | 0.80 | KDM4E (0.66) | ALDH1A1MAPTLMNAKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160314-A1 | Small Molecule Inhibitors of Toll-Like Receptor 9 | LIPFORD GRAYSON B | 2010-06-24 | — | — | US | disclosed |
| US-20100160314-A1 | Small Molecule Inhibitors of Toll-Like Receptor 9 | LIPFORD GRAYSON B | 2010-06-24 | — | — | US | disclosed |
| US-20100160314-A1 | Small Molecule Inhibitors of Toll-Like Receptor 9 | LIPFORD GRAYSON B | 2010-06-24 | — | — | US | disclosed |
| EP-2081924-A2 | SMALL MOLECULE INHIBITORS OF TOLL-LIKE RECEPTOR 9 | Coley Pharmaceutical Group, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008030455-A2 | SMALL MOLECULE INHIBITORS OF TOLL-LIKE RECEPTOR 9 | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2008-03-13 | — | — | WO | disclosed |
| WO-2008030455-A2 | SMALL MOLECULE INHIBITORS OF TOLL-LIKE RECEPTOR 9 | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160314-A1 | Small Molecule Inhibitors of Toll-Like Receptor 9 | TLR9, TLR3, TLR1 | RXFP1 2581/4885ALDH1A1 4793/4885MAPT 3558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.