Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 16/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 16/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 16/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 16/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 16/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 16/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13405599 | 1.00 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13405602 | 0.90 | MAPK1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3498332 | 0.82 | PSEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3496935 | 0.74 | PDE2A (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13405600 | 0.73 | MAPK1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3496996 | 0.69 | PAX8 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3498209 | 0.66 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3497498 | 0.66 | PSEN1 (0.73) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8156774 | 0.64 | PSEN1 (0.73) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3498542 | 0.64 | PSEN1 (0.73) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420622-B2 | Silylated piperidine derivatives | Merck, Sharp & Dohme, Corp. (US) | 2013-04-16 | — | — | US | disclosed |
| EP-2120584-B1 | SILYLATED PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME (US) | 2012-06-20 | — | — | EP | disclosed |
| US-20100093665-A1 | SILYLATED PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME CORP. | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093665-A1 | SILYLATED PIPERIDINE DERIVATIVES | PSEN1, PSEN2, SRM | PSEN1 1/4885PSEN2 2/4885APH1B 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.