Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 7/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | USP8 | P40818 | 5/20 | 0.34 |
| ▸ | USP2 | O75604 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3499992 | 0.86 | NFKBIA (0.38) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL3499064 | 0.86 | NR1H3 (0.31) | ALDH1A1LMNAHPGD | |
| SCHEMBL13360131 | 0.85 | SMN1; SMN2 (0.36) | CNKSR1AKT1USP8USP2ALDH1A1 | |
| SCHEMBL2961426 | 0.85 | CNKSR1 (0.35) | CNKSR1AKT1USP8USP2MAPT | |
| SCHEMBL13204571 | 0.83 | CNKSR1 (0.39) | CNKSR1AKT1USP8USP2ALDH1A1 | |
| SCHEMBL2967625 | 0.83 | CNKSR1 (0.35) | CNKSR1AKT1USP8USP2ALDH1A1 | |
| SCHEMBL13531777 | 0.82 | SMN1; SMN2 (0.34) | CNKSR1AKT1USP8USP2ALDH1A1 | |
| SCHEMBL12971413 | 0.77 | SMN1; SMN2 (0.38) | USP8USP2ALDH1A1MEN1KMT2A | |
| SCHEMBL12971412 | 0.77 | SMN1; SMN2 (0.38) | USP8USP2ALDH1A1MEN1KMT2A | |
| SCHEMBL3499094 | 0.76 | LMNA (0.32) | ALDH1A1LMNAMAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410087-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-04-02 | — | — | US | disclosed |
| US-20100144702-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144702-A1 | INDOLE COMPOUND | GCKR, GPR119, SLC5A1 | CNKSR1 1143/4885AKT1 485/4885USP8 2532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.