Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 7/20 | 0.75 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | XBP1 | P17861 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3496871 | 0.82 | POLA1 (1.00) | POLA1 | |
| SCHEMBL3496869 | 0.79 | POLA1 (0.70) | POLA1MAPTHTTHPGDXBP1 | |
| SCHEMBL28004894 | 0.78 | POLA1 (0.48) | POLA1MAPTHTTLMNA | |
| SCHEMBL28004909 | 0.78 | MKNK1 (0.46) | POLA1MAPTHTTXBP1SMN1; SMN2 | |
| SCHEMBL28004905 | 0.78 | POLA1 (0.44) | POLA1HTTLMNA | |
| SCHEMBL7680705 | 0.75 | PDE4A (0.49) | POLA1 | |
| SCHEMBL28004982 | 0.72 | XDH (0.53) | POLA1HTT | |
| SCHEMBL28004933 | 0.72 | XDH (0.46) | POLA1 | |
| SCHEMBL17478578 | 0.71 | CCNB2 (0.44) | — | |
| SCHEMBL8663355 | 0.70 | GDA (0.46) | HPGDSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100143332-A1 | COMBINATION THERAPY FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
| EP-2086644-A2 | COMBINATION OF AN INHIBITOR OF DNA POLYMERASE-ALPHA AND AN INHIBITOR OF A CHECKPOINT KINASE FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008063558-A2 | COMBINATION OF AN INHIBITOR OF DNA POLYMERASE-ALPHA AND AN INHIBITOR OF A CHECKPOINT KINASE FOR PROLIFERATIVE DISORDERS | SCHERING CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |