Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KLK7 | P49862 | 2/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30043940 | 0.88 | SIRT2 (0.64) | MAPTKLK7KLK5CA1CA2 | |
| SCHEMBL13430768 | 0.88 | SIRT2 (0.64) | MAPTKLK7KLK5CA1CA2 | |
| SCHEMBL8091300 | 0.87 | MAPT (0.61) | MAPTKLK7KLK5CA1CA2 | |
| SCHEMBL8083532 | 0.87 | MAPT (0.61) | MAPTKLK7KLK5CA1CA2 | |
| SCHEMBL25540903 | 0.86 | KLK7 (0.67) | MAPTKLK7KLK5CA1CA2 | |
| SCHEMBL2329138 | 0.86 | KLK7 (0.67) | MAPTKLK7KLK5CA1CA2 | |
| SCHEMBL2329143 | 0.86 | KLK7 (0.67) | MAPTKLK7KLK5CA1CA2 | |
| SCHEMBL30689133 | 0.86 | MAPT (0.58) | MAPTKLK7KLK5POLBMAPK1 | |
| SCHEMBL7549143 | 0.86 | KLK7 (0.64) | MAPTKLK7KLK5POLBMAPK1 | |
| SCHEMBL22355258 | 0.85 | MAPT (0.54) | MAPTKLK7KLK5CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100104585-A1 | Methods and Reagents for Regulation of Cellular Responses in Biological Systems | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-04-29 | — | — | US | disclosed |
| US-20040248801-A1 | Methods and reagents for regulation of cellular responses in biological systems | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248801-A1 | Methods and reagents for regulation of cellular responses in biological systems | HAVCR2, CASR, SRPRA | MAPT 3752/4885KLK7 2952/4885KLK5 3592/4885 |
| US-20100104585-A1 | Methods and Reagents for Regulation of Cellular Responses in Biological Systems | HAVCR2, CD4, CX3CR1 | MAPT 3011/4885KLK7 2055/4885KLK5 2943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.