Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.59 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29432634 | 1.00 | DYRK1A (0.59) | DYRK1AMKNK1MKNK2MAP4K4BACE1 | |
| SCHEMBL30337203 | 0.89 | DYRK1A (0.70) | DYRK1AMKNK1MKNK2PDPK1AAK1 | |
| SCHEMBL30935767 | 0.84 | DYRK1A (0.63) | DYRK1AMKNK1MKNK2PDPK1AAK1 | |
| SCHEMBL4402187 | 0.84 | DYRK1A (0.63) | DYRK1AMKNK1MKNK2PDPK1AAK1 | |
| SCHEMBL15649966 | 0.83 | DYRK1A (0.63) | DYRK1AMKNK1MKNK2PDPK1AAK1 | |
| Hydrochloric Acid SCHEMBL10461111 | 0.82 | DYRK1A (0.61) | DYRK1AMKNK1MKNK2PDPK1AAK1 | |
| SCHEMBL17632269 | 0.81 | DYRK1A (0.54) | DYRK1AMKNK1MKNK2ROCK1PDPK1 | |
| SCHEMBL29733143 | 0.80 | DYRK1A (0.60) | DYRK1AMKNK1MKNK2MAP4K4PDPK1 | |
| SCHEMBL4411668 | 0.80 | DYRK1A (0.60) | DYRK1AMKNK1MKNK2MAP4K4PDPK1 | |
| SCHEMBL18854871 | 0.79 | MKNK1 (0.62) | DYRK1AMKNK1MKNK2PDPK1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12291516-B2 | Substituted 1-amino-1H-imidazole-5-carboxamide as Bruton's tyrosine kinase inhibitors | HENAN ZHIWEI BIOMEDICINE CO., LTD. (CN) | 2025-05-06 | — | — | US | disclosed |
| EP-3966204-B1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | HENAN ZHIWEI BIOMEDICINE CO LTD (CN) | 2024-11-27 | — | — | EP | disclosed |
| CN-111909133-B | Substituted 1-amino-1H-imidazole-5-carboxamides as inhibitors of brunauer tyrosine kinase | 河南知微生物医药有限公司 | 2023-07-14 | — | — | CN | disclosed |
| US-20220259181-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | HENAN ZHIWEI BIOMEDICINE CO., LTD. (CN) | 2022-08-18 | — | — | US | disclosed |
| WO-2020228637-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | HENAN NORMAL UNIVERSITY (CN) | 2020-11-19 | — | — | WO | disclosed |
| CN-111909133-A | Substituted 1-amino-1H-imidazole-5-carboxamides as brunauer tyrosine kinase inhibitors | 河南师范大学 | 2020-11-10 | — | — | CN | disclosed |
| CN-109071444-A | N- (cyanobenzyl) -6- (cyclopropyl-carbonylamino) -4- (phenyl) -pyridine-2-carboxamide derivatives and related compounds as pesticides and plant protection agents | 拜耳作物科学股份公司 | 2018-12-21 | — | — | CN | disclosed |
| US-20100130737-A1 | Regulating Agent of GPR34 Receptor Function | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-27 | — | — | US | disclosed |
| EP-1849465-A1 | AGENT FOR CONTROLLING FUNCTION OF GPR34 RECEPTOR | Takeda Pharmaceutical Company Limited (JP) | 2007-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259181-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | BTK, SYK, TYK2 | DYRK1A 114/4885MKNK1 674/4885MKNK2 767/4885 |
| US-20100130737-A1 | Regulating Agent of GPR34 Receptor Function | GPR34, GPR4, GPR6 | DYRK1A 3028/4885MKNK1 2299/4885MKNK2 2135/4885 |
| US-12291516-B2 | Substituted 1-amino-1H-imidazole-5-carboxamide as Bruton's tyrosine kinase inhibitors | BTK, SYK, TYK2 | DYRK1A 114/4885MKNK1 674/4885MKNK2 767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.