Cynaropicrin

Cynaropicrin

SCHEMBL349976

C=C(CO)C(=O)O[C@H]1CC(=C)[C@@H]2C[C@H](O)C(=C)[C@@H]2[C@@H]2OC(=O)C(=C)[C@@H]21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ NPC1 O15118 2/20 0.41
▸ HTT P42858 2/20 0.41
▸ RAB9A P51151 2/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ POLB P06746 1/20 0.41
▸ PKM P14618 1/20 0.41
▸ RECQL P46063 1/20 0.41
▸ ATM Q13315 1/20 0.41
▸ TDP1 Q9NUW8 1/20 0.41
▸ MITF O75030 1/20 0.41
▸ PAX8 Q06710 1/20 0.41
▸ PTPN1 P18031 4/20 0.38
▸ PTPN2 P17706 1/20 0.35
▸ GPX4 P36969 1/20 0.34
▸ GPR52 Q9Y2T5 1/20 0.32
▸ FNTA P49354 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cynaropicrin SCHEMBL1711811 1.00 MAPT (0.42) MAPTMEN1ALDH1A1KMT2ANPC1
Cynaropicrin SCHEMBL1711522 1.00 MAPT (0.42) MAPTMEN1ALDH1A1KMT2ANPC1
SCHEMBL10307519 0.91 MAPT (0.43) MAPTMEN1ALDH1A1KMT2ANPC1
Aguerin B SCHEMBL29352650 0.87 MAPT (0.54) MAPTMEN1ALDH1A1KMT2ANPC1
SCHEMBL10307583 0.81 MAPT (0.35) MAPTMEN1ALDH1A1KMT2ANPC1
SCHEMBL31092250 0.81 MAPT (0.43) MAPTMEN1ALDH1A1KMT2ANPC1
SCHEMBL12516825 0.81 MAPT (0.42) MAPTMEN1ALDH1A1KMT2ANPC1
SCHEMBL31273011 0.81 MAPT (0.42) MAPTMEN1ALDH1A1KMT2ANPC1
Janerin SCHEMBL30019199 0.80 MAPT (0.51) MAPTMEN1ALDH1A1KMT2ANPC1
SCHEMBL12459711 0.80 MAPT (0.41) MAPTMEN1ALDH1A1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 452 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118266586-B Composite plant product and preparation method and application thereof COFCO NUTRITION AND HEALTH RESEARCH INSTITUTE Co.,Ltd. (CN) 2026-05-26 — — CN claimed
CN-122031581-A Composition for preventing, treating and/or relieving hyperuricemia and application thereof 广西医科大学 2026-05-15 — — CN claimed
CN-122011075-A Wilfoside C1N and Cynanchum otophyllum glycoside A, and separation method and application thereof in preparation of medicine for treating constipation 云南农业大学 2026-05-12 — — CN claimed
CN-119656183-A Application of effective ingredient formula of known cellulitis in treating peripheral neuropathy caused by diabetes 唐宁医药科技(济南)有限公司 2025-03-21 — — CN claimed
US-20240293579-A1 Composition Comprising Trim31 and Rhbdf2 for Treatment of NAFLD/NASH CHONGQING MEIPULAN TECHNOLOGY CO., LTD (CN) 2024-09-05 — — US claimed
CN-118266586-A Composite plant product and preparation method and application thereof 中粮营养健康研究院有限公司 2024-07-02 — — CN claimed
US-11712056-B2 Extract obtained from several plants for use in the prevention and/or treatment of chronic inflammatory bowel diseases VALBIOTIS (FR) 2023-08-01 — — US claimed
EP-3982924-B1 PLANT EXTRACT MIXTURE FOR USE IN THE PREVENTION AND/OR TREATMENT OF CHRONIC INFLAMMATORY BOWEL DISEASES VALBIOTIS (FR) 2023-07-26 — — EP claimed
CN-113651804-B Industrial preparation method of cynaropicrin 陕西嘉禾生物科技股份有限公司 2023-07-14 — — CN claimed
CN-116121362-A Application of TRIM26 in preparation of NASH biomarker and medicament 重庆第二师范学院 2023-05-16 — — CN claimed
EP-1906983-A2 CYNARA SCOLYMUS EXTRACTS, THE USE THEREOF ANS FORMULATIONS CONTAINING THEM INDENA S.p.A. (IT) 2008-04-09 — — EP claimed
WO-2008012666-A2 TREATMENT AND PREVENTION MUCOSITIS BY ANTHOCYANIDIN DERIVATIVES INDENA S.P.A. (IT) 2008-01-31 — — WO claimed
US-20080026058-A1 METHODS FOR TREATING AND PREVENTING MUCOSITIS INDENA S.P.A. (IT) 2008-01-31 — — US claimed
EP-1882473-A1 Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs Indena S.P.A. (IT) 2008-01-30 — — EP claimed
WO-2007006391-A2 CYNARA SCOLYMUS EXTRACTS, THE USE THEREOF ANS FORMULATIONS CONTAINING THEM INDENA S.P.A. (IT) 2007-01-18 — — WO claimed
US-6908630-B2 Combinations of sesquiterpene lactones and ditepene triepoxide lactones for synergistic inhibition of cyclooxygenase-2 METAPROTEOMICS, LLC (US) 2005-06-21 — — US claimed
US-20020077350-A1 Compositions exhibiting synergistic inhibition of the expression and/or activity of clyclooxygenase-2 ASHNI NATURACEUTICALS, INC. 2002-06-20 — — US claimed
US-20020077299-A1 Combinations of sesquiterpene lactones and ditepene triepoxide lactones for synergistic inhibition of cyclooxygenase-2 META PROTEOMICS, LLC 2002-06-20 — — US claimed
WO-2002009698-A1 COMPOSITIONS EXHIBITING SYNERGISTIC INHIBITION OF THE EXPRESSION AND/OR ACTIVITY OF CYCLOOXYGENASE-2 ASHNI NATURACEUTICALS, INC. (US) 2002-02-07 — — WO claimed
US-4133903-A Process for preparing bitter beverages SIEGFRIED AKTIENGESELLSCHAFT (CH) 1979-01-09 — — US claimed
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