Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | RARA | P10276 | 6/20 | 0.67 |
| ▸ | RXRA | P19793 | 5/20 | 0.67 |
| ▸ | RARB | P10826 | 4/20 | 0.67 |
| ▸ | RARG | P13631 | 4/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | RXRB | P28702 | 2/20 | 0.67 |
| ▸ | RXRG | P48443 | 2/20 | 0.67 |
| ▸ | RORC | P51449 | 2/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | HTR2B | P41595 | 2/20 | 0.67 |
| ▸ | BLM | P54132 | 2/20 | 0.67 |
| ▸ | GMNN | O75496 | 2/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7127846 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL23356521 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL1718341 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL1718339 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL1765991 | 0.90 | MAPT (0.82) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL1765989 | 0.90 | MAPT (0.82) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL21140941 | 0.89 | ALDH1A1 (0.80) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL1498298 | 0.88 | MAPT (0.79) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL13903879 | 0.87 | MAPT (0.77) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL3701619 | 0.87 | ALDH1A1 (0.77) | ALDH1A1MAPTSMN1; SMN2RARARXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030105166-A1 | Controlling cell differentiation | EISAI INC. | 2003-06-05 | — | — | US | claimed |
| US-6506917-B1 | Ligands which are more selective for retinoid X receptor than is retinoic acid | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES | 2003-01-14 | — | — | US | claimed |
| EP-0617614-B1 | MEANS FOR THE MODULATION OF PROCESSES MEDIATED BY RETINOID RECEPTORS AND COMPOUNDS USEFUL THEREFOR | SALK INST FOR BIOLOGICAL STUDI (US) | 1998-03-04 | — | — | EP | claimed |
| EP-0807624-A2 | Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1997-11-19 | — | — | EP | claimed |
| EP-0617614-A1 | MEANS FOR THE MODULATION OF PROCESSES MEDIATED BY RETINOID RECEPTORS AND COMPOUNDS USEFUL THEREFOR | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1994-10-05 | — | — | EP | claimed |
| WO-1993011755-A1 | MEANS FOR THE MODULATION OF PROCESSES MEDIATED BY RETINOID RECEPTORS AND COMPOUNDS USEFUL THEREFOR | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1993-06-24 | — | — | WO | claimed |
| US-20130288362-A1 | COMPOSITIONS AND METHODS FOR PRODUCING ADAPTIVE REGULATORY T CELLS | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-10-31 | — | — | US | disclosed |
| US-8415154-B2 | Compositions and methods for producing adaptive regulatory T cells | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-04-09 | — | — | US | disclosed |
| US-20100183575-A1 | Compositions and Methods for Producing Adaptive Regulatory T Cells | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-07-22 | — | — | US | disclosed |
| EP-0807624-B1 | RETINOIC ACID DERIVATIVES | SALK INST FOR BIOLOGICAL STUDI (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008150853-A1 | COMPOSITIONS AND METHODS FOR PRODUCING ADAPTIVE REGULATORY T CELLS | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2008-12-11 | — | — | WO | disclosed |
| US-20060211768-A1 | Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES | 2006-09-21 | — | — | US | disclosed |
| US-7056954-B2 | Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2006-06-06 | — | — | US | disclosed |
| US-6506917-B1 | Ligands which are more selective for retinoid X receptor than is retinoic acid | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES | 2003-01-14 | — | — | US | disclosed |
| US-5968989-A | ADMINISTERING PHARMACEUTICAL COMPOSITION COMPRISING A COMPOUND MORE POTENT AS A MODULATOR FOR RETINOID X RECEPTOR (RXR) IN A COTRANSFECTION ASSAY THAN IS ALL-TRANS-RETINOIC ACID, AND A CARRIER; SKIN DISORDERS | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1999-10-19 | — | — | US | disclosed |
| US-5932622-A | PREVENTION WRINKLING, ACNE; ANTITUMOR AGENT | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0617614-B1 | MEANS FOR THE MODULATION OF PROCESSES MEDIATED BY RETINOID RECEPTORS AND COMPOUNDS USEFUL THEREFOR | SALK INST FOR BIOLOGICAL STUDI (US) | 1998-03-04 | — | — | EP | disclosed |
| EP-0807624-A2 | Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0617614-A1 | MEANS FOR THE MODULATION OF PROCESSES MEDIATED BY RETINOID RECEPTORS AND COMPOUNDS USEFUL THEREFOR | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1994-10-05 | — | — | EP | disclosed |
| WO-1993011755-A1 | MEANS FOR THE MODULATION OF PROCESSES MEDIATED BY RETINOID RECEPTORS AND COMPOUNDS USEFUL THEREFOR | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1993-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105166-A1 | Controlling cell differentiation | RXRA, RARB, RXRB | ALDH1A1 511/4885MAPT 4867/4885SMN1; SMN2 3369/4885 |
| US-20060211768-A1 | Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor | RXRG, RXRA, RXRB | ALDH1A1 435/4885MAPT 4863/4885SMN1; SMN2 4744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.