SCHEMBL3500237

SCHEMBL3500237

CC(=O)OC(C)CC#N

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23732399 0.80
SCHEMBL6358498 0.80 CTSK (0.36)
SCHEMBL28952300 0.80
SCHEMBL10988177 0.79 MGAM (0.41)
SCHEMBL28321992 0.79 TSHR (0.42)
SCHEMBL6384157 0.79
SCHEMBL8377632 0.77
SCHEMBL968522 0.77
SCHEMBL11582766 0.77 ALOX15 (0.53)
SCHEMBL21813953 0.77 CTSK (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100143989-A1 Production Of 3-Hydroxycarboxylic Acid Using Nitrilase Mutants E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-06-10 US disclosed
EP-1778840-B1 PRODUCTION OF 3-HYDROXYCARBOXYLIC ACID USING NITRILASE MUTANTS DU PONT (US) 2008-06-11 EP disclosed
US-7358071-B2 Production of 3-hydroxycarboxylic acid using nitrilase mutants E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-04-15 US disclosed
US-20070117192-A1 Production of 3-hydroxycarboxylic acid using nitrilase mutants PURETECH SCIENTIFIC LLC 2007-05-24 US disclosed
EP-1778840-A2 PRODUCTION OF 3-HYDROXYCARBOXYLIC ACID USING NITRILASE MUTANTS E.I.Du pont de nemours and company (US) 2007-05-02 EP disclosed
US-20070004017-A1 3-hydroxycarboxylic acid production and use in branched polymers BRAMUCCI MICHAEL G 2007-01-04 US disclosed
US-7148051-B2 Production of 3-hydroxycarboxylic acid using nitrilase E. I. DU PONT DE NEMOURS AND COMPANY (US) 2006-12-12 US disclosed
US-7138480-B2 3-Hydroxycarboxylic acid production and use in branched polymers E. I. DU PONT DE NEMOURS AND COMPANY (US) 2006-11-21 US disclosed
US-7091011-B2 3-hydroxycarboxylic acid production and use in branched polymers E. I. DU PONT DE NEMOURS AND COMPANY (US) 2006-08-15 US disclosed
WO-2006023520-A2 PRODUCTION OF 3-HYDROXYCARBOXYLIC ACID USING NITRILASE MUTANTS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-03-02 WO disclosed
US-20060035352-A1 Production of 3-hydroxycarboxylic acid using nitrilase PURETECH SCIENTIFIC LLC 2006-02-16 US disclosed
US-20030170837-A1 3-hydroxycarboxylic acid production and use in branched polymers AXALTA COATING SYSTEMS IP CO. LLC (FORMERLY KNOWN AS U.S. COATINGS IP CO. LLC) 2003-09-11 US disclosed
US-20030166180-A1 3-Hydroxycarboxylic acid production and use in branched polymers AXALTA COATING SYSTEMS IP CO. LLC (FORMERLY KNOWN AS U.S. COATINGS IP CO. LLC) 2003-09-04 US disclosed
EP-1309715-A2 3-HYDROXYCARBOXYLIC ACID PRODUCTION AND USE IN BRANCHED POLYMERS E.I. Dupont de Nemours and Company (US) 2003-05-14 EP disclosed
US-6562603-B2 Forming hydroxy group containing acid from hydroxy groupcontaining nitrile; polylactones E. I. DU PONT DE NEMOURS AND COMPANY 2003-05-13 US disclosed
US-20020039770-A1 3-Hydroxycarboxylic acid production and use in branched polymers AXALTA COATING SYSTEMS IP CO. LLC (FORMERLY KNOWN AS U.S. COATINGS IP CO. LLC) 2002-04-04 US disclosed
WO-2002012530-A2 3-HYDROXYCARBOXYLIC ACID PRODUCTION AND USE IN BRANCHED POLYMERS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2002-02-14 WO disclosed