Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 7/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.42 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycolic Acid SCHEMBL11244860 | 0.79 | MEN1 (0.49) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL4714675 | 0.79 | MEN1 (0.56) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| Bicarbonate SCHEMBL11101479 | 0.78 | L3MBTL3 (0.50) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| Bicarbonate SCHEMBL19689366 | 0.78 | L3MBTL3 (0.50) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL8297279 | 0.77 | ALDH1A1 (0.49) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL8297280 | 0.77 | ALDH1A1 (0.49) | MEN1KMT2AL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL827994 | 0.76 | — | — | |
| SCHEMBL20756261 | 0.76 | L3MBTL3 (0.50) | L3MBTL3L3MBTL1MBTD1KDM4ETP53BP1 | |
| SCHEMBL26394048 | 0.76 | L3MBTL3 (0.50) | L3MBTL3L3MBTL1MBTD1KDM4ETP53BP1 | |
| SCHEMBL26109078 | 0.76 | L3MBTL3 (0.50) | L3MBTL3L3MBTL1MBTD1KDM4ETP53BP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776886-B2 | Cyclopropyl piperidine glycine transporter inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20080108663-A1 | Cyclopropyl Piperidine Glycine Transporter Inhibitors | MERCK SHARP & DOHME LLC | 2008-05-08 | — | — | US | disclosed |
| CN-101031547-A | Cyclopropyl piperidine glycine transporter inhibitors | MERCK & CO INC (US) | 2007-09-05 | — | — | CN | disclosed |
| CN-101031547-A | Cyclopropyl piperidine glycine transporter inhibitors | MERCK & CO INC (US) | 2007-09-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108663-A1 | Cyclopropyl Piperidine Glycine Transporter Inhibitors | SLC1A2, SLC1A1, SLC1A3 | MEN1 4267/4885KMT2A 1333/4885L3MBTL3 3320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.