Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1976480 | 0.75 | FFAR3 (0.39) | PGRADORA3HSD17B10ALOX15TDP1 | |
| SCHEMBL1976479 | 0.75 | FFAR3 (0.39) | PGRADORA3HSD17B10ALOX15TDP1 | |
| SCHEMBL25433374 | 0.74 | CA12 (0.47) | CA12CA1CA2CA9MGAM | |
| SCHEMBL10892994 | 0.74 | MGAM (0.46) | CA12CA1CA2CA9MGAM | |
| SCHEMBL710344 | 0.74 | NR1I2 (0.55) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL3505842 | 0.74 | NR1I2 (0.55) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL710343 | 0.74 | NR1I2 (0.55) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL10892991 | 0.74 | MGAM (0.46) | CA12CA1CA2CA9MGAM | |
| SCHEMBL14899313 | 0.71 | NR1I2 (0.71) | ALDH1A1NR1I2PGRADORA3PTGS2 | |
| SCHEMBL65107 | 0.69 | CA12 (0.61) | CA12CA1CA2CA9MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3159352-B1 | STITCHED POLYPEPTIDES | HARVARD COLLEGE (US) | 2023-08-02 | — | — | EP | disclosed |
| US-10301351-B2 | Stitched polypeptides | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-05-28 | — | — | US | disclosed |
| EP-3159352-A1 | STITCHED POLYPEPTIDES | President and Fellows of Harvard College (US) | 2017-04-26 | — | — | EP | disclosed |
| US-20170066799-A1 | STITCHED POLYPEPTIDES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-03-09 | — | — | US | disclosed |
| US-9556227-B2 | Stitched polypeptides | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2508531-B1 | Stitched polypeptides | HARVARD COLLEGE (US) | 2016-10-19 | — | — | EP | disclosed |
| US-20140011979-A1 | STITCHED POLYPEPTIDES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-01-09 | — | — | US | disclosed |
| US-8592377-B2 | Stitched polypeptides | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-11-26 | — | — | US | disclosed |
| EP-2142562-B1 | STITCHED POLYPEPTIDES | HARVARD COLLEGE (US) | 2013-07-03 | — | — | EP | disclosed |
| EP-2508531-A1 | Stitched polypeptides | President and Fellows of Harvard College (US) | 2012-10-10 | — | — | EP | disclosed |
| US-20100184645-A1 | STITCHED POLYPEPTIDES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-07-22 | — | — | US | disclosed |
| EP-2142562-A2 | STITCHED POLYPEPTIDES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008121767-A2 | STITCHED POLYPEPTIDES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066799-A1 | STITCHED POLYPEPTIDES | VIP, IAPP, NGLY1 | CA12 1731/4885CA1 3243/4885CA2 3939/4885 |
| US-20100184645-A1 | STITCHED POLYPEPTIDES | VIP, IAPP, NGLY1 | CA12 1731/4885CA1 3243/4885CA2 3939/4885 |
| US-10301351-B2 | Stitched polypeptides | VIP, IAPP, NGLY1 | CA12 1731/4885CA1 3243/4885CA2 3939/4885 |
| US-20140011979-A1 | STITCHED POLYPEPTIDES | VIP, IAPP, NGLY1 | CA12 1731/4885CA1 3243/4885CA2 3939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.