Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.63 |
| ▸ | TYK2 | P29597 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NAMPT | P43490 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.54 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5007790 | 0.87 | ROCK2 (0.64) | ROCK2ROCK1HTTJAK2TYK2 | |
| SCHEMBL3502315 | 0.85 | NAMPT (0.60) | ROCK2ROCK1HTTJAK2TYK2 | |
| SCHEMBL3502467 | 0.85 | ROCK2 (0.63) | ROCK2ROCK1HTTJAK2TYK2 | |
| SCHEMBL3502765 | 0.85 | NAMPT (0.60) | ROCK2ROCK1HTTJAK2TYK2 | |
| SCHEMBL2793413 | 0.85 | ROCK2 (0.63) | ROCK2ROCK1HTTJAK2TYK2 | |
| SCHEMBL3502319 | 0.85 | NAMPT (0.60) | ROCK2ROCK1HTTJAK2TYK2 | |
| SCHEMBL5466401 | 0.85 | ROCK2 (0.69) | ROCK2ROCK1HTTJAK2TYK2 | |
| Hydrochloric Acid SCHEMBL3502897 | 0.84 | NAMPT (0.59) | ROCK2ROCK1HTTJAK2TYK2 | |
| Hydrochloric Acid SCHEMBL3504708 | 0.84 | NAMPT (0.59) | ROCK2ROCK1HTTJAK2TYK2 | |
| Hydrochloric Acid SCHEMBL27714090 | 0.84 | NAMPT (0.59) | ROCK2ROCK1HTTJAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190788-A1 | Amide derivatives as kinase inhitors | DEVGEN N.V. (BE) | 2010-07-29 | — | — | US | claimed |
| US-20100190788-A1 | Amide derivatives as kinase inhitors | DEVGEN N.V. (BE) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190788-A1 | Amide derivatives as kinase inhitors | MAP3K1, MAPK1, MAP3K21 | ROCK2 24/4885ROCK1 10/4885HTT 875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.