Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.63 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.57 |
| ▸ | PRKX | P51817 | 1/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2793413 | 1.00 | ROCK2 (0.63) | ROCK2ROCK1RPS6KA5MAP4K4CDK1 | |
| SCHEMBL3502852 | 0.85 | ROCK1 (0.56) | ROCK2ROCK1RPS6KA5MAP4K4CDK1 | |
| SCHEMBL3502826 | 0.85 | ROCK1 (0.56) | ROCK2ROCK1RPS6KA5MAP4K4CDK1 | |
| SCHEMBL3501386 | 0.85 | ROCK2 (0.64) | ROCK2ROCK1KMT2AALDH1A1JAK2 | |
| SCHEMBL3502837 | 0.84 | ROCK2 (0.67) | ROCK2ROCK1MAPK1KMT2AALDH1A1 | |
| SCHEMBL2792957 | 0.83 | ROCK2 (0.59) | ROCK2ROCK1RPS6KA5MAP4K4CDK1 | |
| SCHEMBL5466401 | 0.81 | ROCK2 (0.69) | ROCK2ROCK1KMT2AALDH1A1JAK2 | |
| SCHEMBL3503618 | 0.80 | ROCK2 (0.60) | ROCK2ROCK1MAPK1KMT2AALDH1A1 | |
| SCHEMBL12972961 | 0.79 | MEN1 (0.62) | KMT2AALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL20418415 | 0.79 | MEN1 (0.62) | KMT2AALDH1A1POLBKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190788-A1 | Amide derivatives as kinase inhitors | DEVGEN N.V. (BE) | 2010-07-29 | — | — | US | claimed |
| CN-101248046-A | Amide derivatives as kinase inhibitors | DEVGEN NV (BE) | 2008-08-20 | — | — | CN | claimed |
| US-20100190788-A1 | Amide derivatives as kinase inhitors | DEVGEN N.V. (BE) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190788-A1 | Amide derivatives as kinase inhitors | MAP3K1, MAPK1, MAP3K21 | ROCK2 24/4885ROCK1 10/4885RPS6KA5 432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.