Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.61 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.61 |
| ▸ | SIRT2 | Q8IXJ6 | 10/20 | 0.59 |
| ▸ | SIRT1 | Q96EB6 | 9/20 | 0.59 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.57 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8269145 | 1.00 | HDAC1 (0.62) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL4837460 | 0.90 | HDAC1 (0.74) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL4837475 | 0.90 | HDAC1 (0.74) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL8269683 | 0.83 | HDAC2 (0.57) | HDAC1HDAC8HDAC3HDAC2HDAC10 | |
| SCHEMBL4838789 | 0.82 | SIRT5 (0.76) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL14254942 | 0.81 | HDAC1 (0.64) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL8312589 | 0.78 | HDAC1 (0.62) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL13928112 | 0.78 | HDAC1 (0.62) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL13864824 | 0.78 | HDAC2 (0.55) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL5557063 | 0.77 | SIRT2 (0.53) | HDAC1HDAC8HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118291-A1 | Histone deacetylase inhibitors | MERCK SHARP & DOHME LLC | 2009-05-07 | — | — | US | claimed |
| EP-1784194-A1 | HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2007-05-16 | — | — | EP | claimed |
| WO-2006026260-A1 | HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2006-03-09 | — | — | WO | claimed |
| US-7795304-B2 | such as S)-[6-Hydroxycarbamoyl-1-(4-phenyl-thiazol-2-ylcarbamoyl)-hexyl]-carbamic acid benzyl ester, useful in the prevention and/or treatment cancer, restenosis, autoimmune diseases, allergies, inflammatory diseases, nervous system disorders such as neurodegenerative diseases | MERCK SHARP & DOHME CORP. (US) | 2010-09-14 | — | — | US | disclosed |
| US-20090118291-A1 | Histone deacetylase inhibitors | MERCK SHARP & DOHME LLC | 2009-05-07 | — | — | US | disclosed |
| EP-1784194-A1 | HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006026260-A1 | HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118291-A1 | Histone deacetylase inhibitors | HDAC1, HDAC5, HDAC9 | HDAC1 1/4885HDAC8 7/4885HDAC3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.