Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 13/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 6/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5555071 | 0.79 | HDAC4 (0.49) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL8269145 | 0.77 | HDAC1 (0.62) | SIRT2SIRT1SIRT3HDAC1HDAC3 | |
| SCHEMBL3504493 | 0.77 | HDAC1 (0.62) | SIRT2SIRT1SIRT3HDAC1HDAC3 | |
| SCHEMBL5555082 | 0.76 | HDAC1 (0.46) | SIRT2SIRT1SIRT3HDAC1HDAC4 | |
| SCHEMBL5555087 | 0.76 | SIRT2 (0.52) | SIRT2SIRT1SIRT3 | |
| SCHEMBL13449697 | 0.72 | CTSL (0.69) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL17694107 | 0.71 | CTSL (0.68) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL17049407 | 0.70 | CTSL (0.58) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL17279329 | 0.70 | SIRT2 (0.74) | SIRT2SIRT1SIRT3CTSLCTSS | |
| SCHEMBL11308449 | 0.70 | SIRT2 (0.74) | SIRT2SIRT1SIRT3CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784194-A1 | HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2007-05-16 | — | — | EP | claimed |
| WO-2006026260-A1 | HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2006-03-09 | — | — | WO | claimed |
| EP-1784194-A1 | HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006026260-A1 | HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2006-03-09 | — | — | WO | disclosed |