Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835392 | 0.86 | FGFR1 (0.48) | FGFR1FGFR3PIK3CGCDK8NTRK1 | |
| SCHEMBL836582 | 0.78 | CDK8 (0.44) | PIK3CGCDK8NR4A2LRRK2FYN | |
| SCHEMBL838368 | 0.67 | FGFR1 (0.49) | FGFR1FGFR3PIK3CGCDK8NTRK1 | |
| SCHEMBL837898 | 0.64 | CDK8 (0.55) | FGFR1FGFR3PIK3CGCDK8NTRK1 | |
| SCHEMBL3645569 | 0.64 | CDK8 (0.43) | FGFR1FGFR3CDK8NR4A2LRRK2 | |
| SCHEMBL12448288 | 0.60 | FGFR1 (0.66) | FGFR1FGFR3PIK3CGCDK8NTRK1 | |
| SCHEMBL13702375 | 0.59 | HDAC8 (0.68) | PIK3CGCDK8NR4A2FYNPIK3CA | |
| SCHEMBL837839 | 0.59 | FGFR1 (0.65) | FGFR1FGFR3PIK3CGCDK8NTRK1 | |
| SCHEMBL835076 | 0.57 | FGFR1 (0.48) | FGFR1FGFR3PIK3CGCDK8NTRK1 | |
| SCHEMBL835840 | 0.57 | FGFR3 (0.73) | FGFR1FGFR3CDK8NTRK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204235-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-08-12 | — | — | US | disclosed |
| EP-2183027-A1 | ORGANIC COMPOUNDS | Novartis Ag (CH) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009013335-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204235-A1 | ORGANIC COMPOUNDS | ALK, OR10J3, FFAR4 | FGFR1 20/4885FGFR3 81/4885PIK3CG 1033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.