Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 3-Hydroxybutyric Acid, (+/-)-. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL2032681 | 0.94 | CAMK2A (0.56) | CAMK2AFFAR1FFAR4GPR84LMNA | |
| (R)-3-Hydroxybutanoate SCHEMBL6231727 | 0.91 | CAMK2A (0.61) | CAMK2AFFAR1FFAR4GPR84LMNA | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL2034805 | 0.91 | CAMK2A (0.61) | CAMK2AFFAR1FFAR4GPR84LMNA | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL28671508 | 0.87 | GPR84 (0.58) | CAMK2AFFAR1FFAR4GPR84LMNA | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL2032943 | 0.87 | SLC22A6 (0.42) | CAMK2AFFAR1FFAR4GPR84CYP1A2 | |
| Oxybate SCHEMBL1643115 | 0.87 | CAMK2A (0.67) | CAMK2AFFAR1FFAR4GPR84TP53 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL8443628 | 0.85 | GPR84 (0.60) | CAMK2AFFAR1FFAR4GPR84LMNA | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL14940374 | 0.83 | CAMK2A (0.47) | CAMK2AFFAR1FFAR4GPR84SLC22A6 | |
| Lactic Acid SCHEMBL21356987 | 0.82 | TP53 (0.58) | CAMK2AFFAR1FFAR4GPR84TP53 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL367756 | 0.81 | CAMK2A (0.48) | CAMK2AFFAR1FFAR4GPR84SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222545-A1 | COPOLYMER COMPRISING 4-HYDROXYBUTYRATE UNIT AND LACTATE UNIT AND ITS MANUFACTURING METHOD | LG CHEM, LTD. (KR) | 2010-09-02 | — | — | US | claimed |
| EP-2084209-A1 | COPOLYMER COMPRISING 4-HYDROXYBUTYRATE UNIT AND LACTATE UNIT AND ITS MANUFACTURING METHOD | LG Chem, Ltd. (KR) | 2009-08-05 | — | — | EP | claimed |
| WO-2008062995-A1 | COPOLYMER COMPRISING 4-HYDROXYBUTYRATE UNIT AND LACTATE UNIT AND ITS MANUFACTURING METHOD | LG CHEM, LTD. (KR) | 2008-05-29 | — | — | WO | claimed |
| EP-2084209-B1 | COPOLYMER COMPRISING 4-HYDROXYBUTYRATE UNIT AND LACTATE UNIT AND ITS MANUFACTURING METHOD | LG CHEMICAL LTD (KR) | 2021-06-02 | — | — | EP | disclosed |
| US-8383379-B2 | Copolymer comprising 4-hydroxybutyrate unit and lactate unit and its manufacturing method | LG CHEM, LTD. (KR) | 2013-02-26 | — | — | US | disclosed |
| US-20100222545-A1 | COPOLYMER COMPRISING 4-HYDROXYBUTYRATE UNIT AND LACTATE UNIT AND ITS MANUFACTURING METHOD | LG CHEM, LTD. (KR) | 2010-09-02 | — | — | US | disclosed |
| EP-2084209-A1 | COPOLYMER COMPRISING 4-HYDROXYBUTYRATE UNIT AND LACTATE UNIT AND ITS MANUFACTURING METHOD | LG Chem, Ltd. (KR) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008062995-A1 | COPOLYMER COMPRISING 4-HYDROXYBUTYRATE UNIT AND LACTATE UNIT AND ITS MANUFACTURING METHOD | LG CHEM, LTD. (KR) | 2008-05-29 | — | — | WO | disclosed |