Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 3-Hydroxybutyric Acid, (+/-)-. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | PPARD | Q03181 | 4/20 | 0.35 |
| ▸ | PPARA | Q07869 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxybate SCHEMBL28452530 | 0.93 | CAMK2A (0.56) | CAMK2AGPR84FFAR1FFAR4SLC22A6 | |
| (R)-3-Hydroxybutanoate SCHEMBL6231727 | 0.89 | CAMK2A (0.61) | CAMK2AGPR84FFAR1FFAR4SLC22A6 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL2034805 | 0.89 | CAMK2A (0.61) | CAMK2AGPR84FFAR1FFAR4SLC22A6 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL2032681 | 0.85 | CAMK2A (0.56) | CAMK2AGPR84FFAR1FFAR4SLC22A6 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL28671508 | 0.85 | GPR84 (0.58) | CAMK2AGPR84FFAR1FFAR4SLC22A6 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL451545 | 0.85 | SLC22A6 (0.55) | GPR84SLC22A6MAPTTSHRTDP1 | |
| (R)-3-Hydroxybutanoate SCHEMBL7776589 | 0.85 | SLC22A6 (0.55) | GPR84SLC22A6MAPTTSHRTDP1 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL14940374 | 0.85 | CAMK2A (0.47) | CAMK2AGPR84FFAR1FFAR4SLC22A6 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL8443628 | 0.83 | GPR84 (0.60) | CAMK2AGPR84FFAR1FFAR4SLC22A6 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL3507151 | 0.81 | CAMK2A (0.50) | CAMK2AGPR84FFAR1FFAR4SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117363554-B | Engineered halophilic microorganism and construction method and application thereof | 清华大学 | 2024-04-09 | — | — | CN | disclosed |
| CN-117825543-A | Method for rapidly detecting polyhydroxyalkanoate in thalli | 北京微构工场生物技术有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-117363554-A | Engineered halophilic microorganism and construction method and application thereof | 清华大学 | 2024-01-09 | — | — | CN | disclosed |
| CN-115651874-B | Culture medium and culture method for culturing halophilic microorganisms | 清华大学 | 2023-04-28 | — | — | CN | disclosed |
| WO-2023013626-A1 | INORGANIC FILLING MATERIAL AND INORGANIC FILLING MATERIAL-REINFORCED THERMOPLASTIC RESIN | 東レ株式会社 | 2023-02-09 | — | — | WO | disclosed |
| US-11319436-B2 | Thermoplastic polyester resin composition and molded article | TORAY INDUSTRIES, INC. (JP) | 2022-05-03 | — | — | US | disclosed |
| EP-3508535-B1 | RESIN COMPOSITION AND MOLDED ARTICLE THEREOF | TORAY INDUSTRIES (JP) | 2020-09-23 | — | — | EP | disclosed |
| US-20200172726-A1 | THERMOPLASTIC POLYESTER RESIN COMPOSITION AND MOLDED ARTICLE | TORAY INDUSTRIES, INC. (JP) | 2020-06-04 | — | — | US | disclosed |
| CN-111065378-A | Method of making a drug delivery composition | PK医疗公司 | 2020-04-24 | — | — | CN | disclosed |
| US-10626273-B2 | Resin composition and molded article thereof | TORAY INDUSTRIES, INC. (JP) | 2020-04-21 | — | — | US | disclosed |
| US-8575246-B2 | Flame-retardant thermoplastic resin composition and molded article | TORAY INDUSTRIES, INC. (JP) | 2013-11-05 | — | — | US | disclosed |
| US-8193264-B2 | Thermoplastic resin composition and molded article thereof | TORAY INDUSTRIES, INC. (JP) | 2012-06-05 | — | — | US | disclosed |
| EP-2444439-A1 | METHOD FOR PRODUCING CRYSTALLIZED POLYESTER | Toray Industries, Inc. (JP) | 2012-04-25 | — | — | EP | disclosed |
| US-20120065342-A1 | METHOD FOR PRODUCING CRYSTALLIZED POLYESTER | TORAY INDUSTRIES, INC. (JP) | 2012-03-15 | — | — | US | disclosed |
| US-8097685-B2 | Dendritic polymer, method for producing the same, and thermoplastic resin composition | TORAY INDUSTRIES, INC. (JP) | 2012-01-17 | — | — | US | disclosed |
| US-20110275743-A1 | FLAME-RETARDANT THERMOPLASTIC RESIN COMPOSITION AND MOLDED ARTICLE | TORAY INDUSTRIES, INC. (JP) | 2011-11-10 | — | — | US | disclosed |
| US-20090118417-A1 | Dendritic Polymer, Method for Producing the Same, and Thermoplastic Resin Composition | TORAY INDUSTRIES, INC. (JP) | 2009-05-07 | — | — | US | disclosed |
| EP-2003158-A9 | DENDRITIC POLYESTER, METHOD FOR PRODUCING THE SAME, AND THERMOPLASTIC RESIN COMPOSITION | TORAY INDUSTRIES, INC. (JP) | 2009-05-06 | — | — | EP | disclosed |
| EP-2036952-A1 | THERMOPLASTIC RESIN COMPOSITION AND MOLDED ARTICLE THEREOF | Toray Industries, Inc. (JP) | 2009-03-18 | — | — | EP | disclosed |
| EP-2003158-A2 | DENDRITIC POLYESTER, METHOD FOR PRODUCING THE SAME, AND THERMOPLASTIC RESIN COMPOSITION | TORAY INDUSTRIES, INC. (JP) | 2008-12-17 | — | — | EP | disclosed |