Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3508760 | 0.79 | HTR2A (0.39) | ALDH1A1 | |
| SCHEMBL3504380 | 0.79 | ALDH1A1 (0.48) | ALDH1A1HTTACP1TP53MAPK1 | |
| SCHEMBL6951018 | 0.78 | HRH3 (0.45) | ALDH1A1KDM4EKMT2AMEN1LMNA | |
| SCHEMBL8377218 | 0.78 | QPCT (0.40) | ALDH1A1QPCTSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL3505069 | 0.77 | GAA (0.45) | ALDH1A1HTTFLT3SMN1; SMN2KDM4E | |
| SCHEMBL8183130 | 0.75 | CYP3A4 (0.47) | ALDH1A1HTTHIF1AACP1TP53 | |
| SCHEMBL8184622 | 0.75 | CYP3A4 (0.45) | ALDH1A1HIF1ATP53ALOX15TSHR | |
| SCHEMBL6956983 | 0.73 | POLB (0.52) | HTTHIF1AACP1TP53MAPK1 | |
| SCHEMBL3510105 | 0.73 | ALDH1A1 (0.50) | ALDH1A1HTTACP1TP53MAPK1 | |
| SCHEMBL3505581 | 0.72 | HSP90AA1 (0.50) | ALDH1A1HIF1AACP1TP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100247543-A1 | TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES | ORYZON GENOMICS, S.A. (ES) | 2010-09-30 | — | — | US | disclosed |