Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 10/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12345100 | 0.86 | S1PR1 (0.46) | S1PR1S1PR3S1PR5AXLMERTK | |
| SCHEMBL6769068 | 0.85 | POLB (0.36) | S1PR1S1PR3S1PR5POLBTDP1 | |
| SCHEMBL12345088 | 0.85 | POLB (0.38) | S1PR1S1PR3S1PR5POLBTDP1 | |
| SCHEMBL12345108 | 0.83 | S1PR1 (0.59) | S1PR1S1PR3HDAC4HDAC6S1PR5 | |
| SCHEMBL5169611 | 0.82 | POLB (0.40) | S1PR1S1PR3S1PR5POLBTDP1 | |
| SCHEMBL3512647 | 0.81 | S1PR1 (0.34) | S1PR1S1PR3HDAC4HDAC6POLB | |
| SCHEMBL13165903 | 0.78 | S1PR1 (0.65) | S1PR1S1PR3S1PR5FFAR1HPGD | |
| SCHEMBL3511485 | 0.75 | S1PR1 (0.36) | S1PR1S1PR3S1PR5 | |
| SCHEMBL3512684 | 0.75 | S1PR1 (0.36) | S1PR1S1PR3S1PR5 | |
| SCHEMBL385980 | 0.75 | S1PR1 (0.49) | S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2045325-B1 | DRUG-PHOSPHORYLATING ENZYME | DAIICHI SANKYO CO LTD (JP) | 2012-09-19 | — | — | EP | disclosed |
| EP-2045325-B1 | DRUG-PHOSPHORYLATING ENZYME | DAIICHI SANKYO CO LTD (JP) | 2012-09-19 | — | — | EP | disclosed |
| US-20100248227-A1 | DRUG-PHOSPHORYLATING ENZYME | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-09-30 | — | — | US | disclosed |
| EP-2045325-A1 | DRUG-PHOSPHORYLATING ENZYME | Daiichi Sankyo Company, Limited (JP) | 2009-04-08 | — | — | EP | disclosed |
| EP-2045325-A1 | DRUG-PHOSPHORYLATING ENZYME | Daiichi Sankyo Company, Limited (JP) | 2009-04-08 | — | — | EP | disclosed |