Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 10/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5169611 | 0.97 | POLB (0.40) | POLBTDP1S1PR1S1PR3S1PR5 | |
| SCHEMBL12345088 | 0.95 | POLB (0.38) | POLBTDP1S1PR1S1PR3S1PR5 | |
| SCHEMBL6770520 | 0.88 | S1PR1 (0.44) | POLBTDP1S1PR1S1PR3S1PR5 | |
| SCHEMBL13165867 | 0.86 | POLB (0.37) | POLBTDP1S1PR1S1PR3ALDH1A1 | |
| SCHEMBL13165870 | 0.86 | HPGD (0.41) | POLBTDP1S1PR1ALDH1A1LMNA | |
| SCHEMBL3510159 | 0.85 | S1PR1 (0.46) | POLBTDP1S1PR1S1PR3S1PR5 | |
| SCHEMBL3511485 | 0.85 | S1PR1 (0.36) | S1PR1S1PR3S1PR5 | |
| SCHEMBL3512684 | 0.85 | S1PR1 (0.36) | S1PR1S1PR3S1PR5 | |
| SCHEMBL5167470 | 0.84 | POLB (0.43) | POLBTDP1S1PR1S1PR3S1PR5 | |
| SCHEMBL5168691 | 0.84 | PDIA6 (0.37) | POLBTDP1S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723745-B2 | PREVENTION OR TREATMENT OF AUTOIMMUNE DISEASE IN WARM BLOODED ANIMAL | SANKYO COMPANY, LIMITED (JP) | 2004-04-20 | — | — | US | claimed |
| EP-2045325-B1 | DRUG-PHOSPHORYLATING ENZYME | DAIICHI SANKYO CO LTD (JP) | 2012-09-19 | — | — | EP | disclosed |
| US-20100248227-A1 | DRUG-PHOSPHORYLATING ENZYME | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-09-30 | — | — | US | disclosed |
| US-20100248227-A1 | DRUG-PHOSPHORYLATING ENZYME | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-09-30 | — | — | US | disclosed |
| EP-2045325-A1 | DRUG-PHOSPHORYLATING ENZYME | Daiichi Sankyo Company, Limited (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-6696463-B2 | FOR THERAPY OF CELL PROLIFERATION, DIFFERENTIATION OR GROWTH DISORDERS, CANCER | SUGEN, INC. | 2004-02-24 | — | — | US | disclosed |