Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 4/20 | 0.46 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
| ▸ | PLAU | P00749 | 3/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3506368 | 0.87 | GLS (0.54) | GLSADORA2AADORA1ALDH1A1POLB | |
| SCHEMBL3507482 | 0.85 | GLS (0.47) | GLSMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL3376313 | 0.83 | GLS (0.54) | GLSMAPTABHD6ADORA2AMEN1 | |
| SCHEMBL656851 | 0.82 | GLS (0.48) | GLSMAPTELANEF2PLAU | |
| SCHEMBL3506950 | 0.81 | PLAU (0.48) | MAPTELANEF2PLAUCTRB1 | |
| SCHEMBL9478940 | 0.80 | NPC1 (0.50) | GLSMAPTELANEF2PLAU | |
| SCHEMBL1728790 | 0.80 | GLS (0.64) | GLSMAPTALDH1A1 | |
| SCHEMBL217553 | 0.79 | GLS (0.57) | GLSMAPTADORA2AADORA1MEN1 | |
| SCHEMBL30729901 | 0.79 | GLS (0.57) | GLSMAPTADORA2AADORA1MEN1 | |
| SCHEMBL31632909 | 0.79 | EPHX2 (0.61) | MAPTABHD6EPHX2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216788-A1 | FUSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | US | disclosed |
| CN-101370812-A | Fused heterocyclic compound | TAKEDA PHARMACEUTICAL (JP) | 2009-02-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216788-A1 | FUSED HETEROCYCLIC COMPOUND | GRK6, FGFR1, PTK6 | GLS 3189/4885MAPT 4440/4885ABHD6 2412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.