Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3507208 | 0.82 | RAB9A (0.50) | RAB9ANPC1HSP90AA1PDE10ASLC5A7 | |
| SCHEMBL3641650 | 0.79 | RAB9A (0.45) | RAB9ANPC1HSP90AA1PDE10ASLC5A7 | |
| SCHEMBL3510413 | 0.77 | RAB9A (0.47) | RAB9ANPC1HSP90AA1PDE10ASLC5A7 | |
| SCHEMBL3686716 | 0.76 | RAB9A (0.48) | RAB9ANPC1HSP90AA1PDE10ASLC5A7 | |
| SCHEMBL166266 | 0.75 | RAB9A (0.54) | RAB9ANPC1HSP90AA1PDE10ASLC5A7 | |
| SCHEMBL166268 | 0.75 | RAB9A (0.54) | RAB9ANPC1HSP90AA1PDE10ASLC5A7 | |
| SCHEMBL3507429 | 0.74 | PDE10A (0.46) | RAB9ANPC1HSP90AA1PDE10ASLC5A7 | |
| SCHEMBL3508843 | 0.73 | PDE10A (0.48) | RAB9ANPC1HSP90AA1PDE10ASLC5A7 | |
| SCHEMBL3647405 | 0.72 | ENPP2 (0.52) | RAB9ANPC1HSP90AA1SLC5A7NAMPT | |
| SCHEMBL2711947 | 0.71 | HPGD (0.56) | RAB9ANPC1HSP90AA1PDE10ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286145-A1 | ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY | COMENTIS, INC. (US) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286145-A1 | ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY | BACE1, BACE2, APP | RAB9A 3199/4885NPC1 204/4885HSP90AA1 2756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.