Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15895072 | 1.00 | CXCR4 (0.45) | CXCR4SIGMAR1LTA4H | |
| SCHEMBL6224053 | 0.92 | CXCR4 (0.44) | CXCR4LTA4H | |
| SCHEMBL21342393 | 0.85 | CXCR4 (0.41) | CXCR4LTA4H | |
| Pyridine SCHEMBL28327399 | 0.84 | CXCR4 (0.39) | CXCR4LTA4H | |
| SCHEMBL2916327 | 0.83 | — | — | |
| SCHEMBL17344117 | 0.80 | CXCR4 (0.45) | CXCR4 | |
| SCHEMBL27869476 | 0.79 | SIGMAR1 (0.34) | CXCR4SIGMAR1 | |
| SCHEMBL27869477 | 0.79 | SIGMAR1 (0.34) | CXCR4SIGMAR1 | |
| SCHEMBL179203 | 0.79 | APEX1 (0.34) | CXCR4 | |
| SCHEMBL9187514 | 0.78 | CXCR4 (0.44) | CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403530-B1 | ENGINEERED PROTEINS WITH HIGH AFFINITY FOR DOTA CHELATES | MASSACHUSETTS INST TECHNOLOGY (US) | 2016-05-11 | — | — | EP | disclosed |
| US-8648176-B2 | Engineered proteins with high affinity for DOTA chelates | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-02-11 | — | — | US | disclosed |
| US-20100254987-A1 | ENGINEERED PROTEINS WITH HIGH AFFINITY FOR DOTA CHELATES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100254987-A1 | ENGINEERED PROTEINS WITH HIGH AFFINITY FOR DOTA CHELATES | TFRC, STAMBP, MAX | CXCR4 1498/4885SIGMAR1 3517/4885LTA4H 4034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.