Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5487439 | 0.81 | KMT2A (0.55) | ALOX15ALDH1A1KDM4EMEN1CYP3A4 | |
| SCHEMBL17867409 | 0.80 | KMT2A (0.57) | ALOX15ALDH1A1KDM4EMEN1CYP3A4 | |
| SCHEMBL30746736 | 0.78 | GRIK1 (0.34) | ALOX15ALDH1A1GRIK1GRIK2KMT2A | |
| SCHEMBL10918478 | 0.76 | — | — | |
| SCHEMBL17265221 | 0.76 | ALOX15 (0.34) | ALOX15ALDH1A1GRIK1GRIK2KDM4E | |
| SCHEMBL17265277 | 0.76 | ALOX15 (0.34) | ALOX15ALDH1A1GRIK1GRIK2KDM4E | |
| SCHEMBL8634500 | 0.75 | PDE4A (0.34) | LMNA | |
| SCHEMBL3273630 | 0.75 | PDE4A (0.34) | LMNA | |
| SCHEMBL6440378 | 0.72 | — | — | |
| SCHEMBL11478724 | 0.72 | ALOX15 (0.47) | ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170081690-A1 | MOENOMYCIN BIOSYNTHESIS-RELATED COMPOSITIONS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-03-23 | — | — | US | disclosed |
| US-9115358-B2 | Moenomycin biosynthesis-related compositions and methods of use thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-08-25 | — | — | US | disclosed |
| US-20100279980-A1 | MOENOMYCIN BIOSYNTHESIS-RELATED COMPOSITIONS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOW OF HARWARD COLLEGE | 2010-11-04 | — | — | US | disclosed |
| WO-2008021367-A2 | MOENOMYCIN BIOSYNTHESIS-RELATED COMPOSITIONS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100279980-A1 | MOENOMYCIN BIOSYNTHESIS-RELATED COMPOSITIONS AND METHODS OF USE THEREOF | MGAM, GALE, GMDS | LMNA 2307/4885L3MBTL1 2052/4885TDP1 2225/4885 |
| US-20170081690-A1 | MOENOMYCIN BIOSYNTHESIS-RELATED COMPOSITIONS AND METHODS OF USE THEREOF | MGAM, GALE, GMDS | LMNA 2307/4885L3MBTL1 2052/4885TDP1 2225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.