⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2241797 | 0.80 | ADRA2A (0.53) | — | |
| SCHEMBL2886695 | 0.79 | — | — | |
| SCHEMBL13667796 | 0.78 | — | — | |
| SCHEMBL8091766 | 0.77 | MIF (0.53) | — | |
| SCHEMBL3159038 | 0.77 | ADRA2A (0.61) | — | |
| SCHEMBL23465162 | 0.76 | ADRA2A (0.47) | — | |
| SCHEMBL8091254 | 0.76 | MIF (0.54) | — | |
| SCHEMBL8100915 | 0.74 | NAAA (0.56) | — | |
| SCHEMBL8107617 | 0.74 | NAAA (0.56) | — | |
| SCHEMBL8104916 | 0.74 | NAAA (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4701635-A1 | 1,2,4-TRIAZOLE-3-THIONE INHIBITORS OF TREX2 FOR USE IN THE TREATMENT OF PSORIASIS, ATOPIC DERMATITIS OR ICHTHYOSIS | Universitat De Barcelona (ES) | 2026-03-04 | — | — | EP | disclosed |
| WO-2024223907-A1 | 1,2,4-TRIAZOLE-3-THIONE INHIBITORS OF TREX2 FOR USE IN THE TREATMENT OF PSORIASIS, ATOPIC DERMATITIS OR ICHTHYOSIS | UNIVERSITAT DE BARCELONA (ES) | 2024-10-31 | — | — | WO | disclosed |
| WO-2023210570-A1 | PLANT STOMATAL OPENING REGULATOR | 国立大学法人東海国立大学機構 | 2023-11-02 | — | — | WO | disclosed |
| CN-112533963-B | (meth) acrylate, monomer composition for dental material, molded article, composition for dental material, and method for producing (meth) acrylate | 三井化学株式会社 | 2023-07-25 | — | — | CN | disclosed |
| US-20230100838-A1 | COVALENT RAS INHIBITORS AND USES THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2023-03-30 | — | — | US | disclosed |
| US-11552334-B1 | Nitrogen-containing compounds as additives for silicon-based Li-ion batteries | ENEVATE CORPORATION (US) | 2023-01-10 | — | — | US | disclosed |
| EP-4065231-A1 | COVALENT RAS INHIBITORS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2022-10-05 | — | — | EP | disclosed |
| CN-114980976-A | Covalent RAS inhibitors and uses thereof | 锐新医药公司 | 2022-08-30 | — | — | CN | disclosed |
| WO-2021108683-A1 | COVALENT RAS INHIBITORS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2021-06-03 | — | — | WO | disclosed |
| CN-104160324-B | Plastic polarized lens and preparation method thereof | MITSUI CHEMICALS, INC. (JP) | 2016-05-11 | — | — | CN | disclosed |
| US-5641776-A | TREATING RHEUMATOID DISEASES | CIBA-GEIGY CORPORATION (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0680473-A1 | NOVEL SUBSTITUTED THIOSEMICARBAZONE DERIVATIVES | Novartis AG (CH) | 1995-11-08 | — | — | EP | disclosed |
| WO-1995014685-A1 | NOVEL SUBSTITUTED THIOSEMICARBAZONE DERIVATIVES | CIBA-GEIGY AG (CH) | 1995-06-01 | — | — | WO | disclosed |
| EP-0470006-B1 | Thiourea derivatives and antimicrobial agent and antiulcer agent containing the same | TERUMO CORP (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5344842-A | Rheumatic diseases | CIBA-GEIGY CORPORATION (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0573392-A1 | Thiosemicarbazones derivatives and their use as pharmaceuticals | CIBA-GEIGY AG (CH) | 1993-12-08 | — | — | EP | disclosed |
| US-5190961-A | Bactericides | TERUMO KABUSHIKI KAISHA (JP) | 1993-03-02 | — | — | US | disclosed |
| EP-0470006-A1 | Thiourea derivatives and antimicrobial agent and antiulcer agent containing the same | TERUMO KABUSHIKI KAISHA (JP) | 1992-02-05 | — | — | EP | disclosed |
| EP-0328954-A1 | 5-Cyano-2,4-diamino-thiazole derivatives | BAYER AG (DE) | 1989-08-23 | — | — | EP | disclosed |
| US-4169899-A | PENICILLAMINE COMPOUNDS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1979-10-02 | — | — | US | disclosed |