Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 3/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.40 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18171690 | 0.77 | PDE10A (0.47) | CYP19A1CYP11B1CYP11B2MAP3K11CGAS | |
| SCHEMBL31107378 | 0.72 | BRD4 (0.74) | BRD4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL858100 | 0.72 | BRD4 (0.74) | BRD4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13854160 | 0.71 | BRD4 (0.61) | BRD4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14365345 | 0.71 | BRD4 (0.61) | BRD4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL18171689 | 0.71 | CYP19A1 (0.50) | CYP19A1CYP11B1CYP11B2CGASKDM4E | |
| SCHEMBL13854453 | 0.70 | BRD4 (0.60) | BRD4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30580377 | 0.70 | BRD4 (0.60) | BRD4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL720887 | 0.69 | BRD4 (1.00) | BRD4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14390405 | 0.68 | BRD4 (0.56) | BRD4PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311729-A1 | Substituted imidazopyridazines and pyrrolopyrimidines as lipid kinase inhibitors | CAPRARO HANS-GEORG | 2010-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311729-A1 | Substituted imidazopyridazines and pyrrolopyrimidines as lipid kinase inhibitors | PI4KA, PIP5K1B, PIP4K2A | BRD4 988/4885PIK3CD 12/4885PIK3CA 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.