Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28133820 | 0.81 | LMNA (0.46) | CYP19A1CYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL18171690 | 0.79 | PDE10A (0.47) | CYP19A1CYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL11702866 | 0.76 | CYP11B1 (0.60) | CYP19A1CYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL1037506 | 0.76 | CYP11B1 (0.60) | CYP19A1CYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL28090553 | 0.73 | CYP19A1 (0.51) | CYP19A1CYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL27754717 | 0.72 | MEN1 (0.49) | CYP19A1CYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL3513470 | 0.71 | BRD4 (0.52) | CYP19A1CYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL28637569 | 0.71 | JAK2 (0.49) | CYP1A2LMNAMAPTALDH1A1FYN | |
| SCHEMBL6756834 | 0.70 | FYN (0.52) | CYP19A1CYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL31149024 | 0.69 | CYP19A1 (0.67) | CYP19A1CYP11B1CYP11B2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3285808-A1 | TREATMENT OF CHRONIC GRAFT VERSUS HOST DISEASE WITH SYK INHIBITORS | Gilead Sciences, Inc. (US) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016172117-A1 | TREATMENT OF CHRONIC GRAFT VERSUS HOST DISEASE WITH SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2016-10-27 | — | — | WO | disclosed |