Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.53 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.73 |
| ▸ | GSR | P00390 | 1/20 | 0.61 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.59 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | XIAP | P98170 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL3485478 | 1.00 | SLC7A5 (0.73) | SLC7A5GSRITGB3ITGA2BPTGS1 | |
| Tyrosine SCHEMBL21925058 | 1.00 | SLC7A5 (0.73) | SLC7A5GSRITGB3ITGA2BPTGS1 | |
| Tyrosine SCHEMBL3303402 | 1.00 | SLC7A5 (0.73) | SLC7A5GSRITGB3ITGA2BPTGS1 | |
| Tyrosine SCHEMBL27709284 | 0.98 | SLC7A5 (0.71) | SLC7A5GSRITGB3ITGA2BPTGS1 | |
| Tyrosine SCHEMBL22207546 | 0.96 | SLC7A5 (0.67) | SLC7A5GSRITGB3ITGA2BPTGS1 | |
| Tyrosine SCHEMBL2723438 | 0.96 | SLC7A5 (0.67) | SLC7A5GSRITGB3ITGA2BPTGS1 | |
| Tyrosine SCHEMBL27074660 | 0.96 | SLC7A5 (0.67) | SLC7A5GSRITGB3ITGA2BPTGS1 | |
| Tyrosine SCHEMBL22654492 | 0.96 | SLC7A5 (0.67) | SLC7A5GSRITGB3ITGA2BPTGS1 | |
| Tyrosine SCHEMBL5066575 | 0.96 | SLC7A5 (0.67) | SLC7A5GSRITGB3ITGA2BPTGS1 | |
| Tyrosine SCHEMBL27765246 | 0.95 | SLC7A5 (0.75) | SLC7A5GSRITGB3ITGA2BPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 321 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298227-A1 | Treatment of autoimmune conditions with Copolymer 1 and related copolymers | President and Fellows of Harvard College and Yeda Research | 2010-11-25 | — | — | US | claimed |
| US-20090060837-A1 | COBALAMIN CONJUGATES USEFUL AS ANTITUMOR AGENTS | COLLINS DOUGLAS A | 2009-03-05 | — | — | US | claimed |
| US-7468432-B2 | Cobalamin conjugates useful as antitumor agents | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2008-12-23 | — | — | US | claimed |
| US-7408018-B2 | Elastomeric functional biodegradable copolyester amides and copolyester urethanes | CORNELL RESEARCH FOUNDATION, INC. (US) | 2008-08-05 | — | — | US | claimed |
| US-20080167270-A1 | ANTI-INFECTIVE PHOSPHONATE ANALOGS | BOOJAMRA CONSTANTINE G | 2008-07-10 | — | — | US | claimed |
| EP-1906971-A2 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2008-04-09 | — | — | EP | claimed |
| US-20080076740-A1 | Antiviral compounds | GILEAD SCIENCES, INC. | 2008-03-27 | — | — | US | claimed |
| US-7304122-B2 | Useful as carriers of drugs or other bioactive substances; polymers can be linked, intermixed, or a combination thereof, to one or more drugs | CORNELL RESEARCH FOUNDATION, INC. (US) | 2007-12-04 | — | — | US | claimed |
| US-7300924-B2 | Anti-infective phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2007-11-27 | — | — | US | claimed |
| EP-1778249-A2 | NUCLEOSIDE PHOSPHONATE CONJUGATES AS ANTI HIV AGENTS | GILEAD SCIENCES, INC. (US) | 2007-05-02 | — | — | EP | claimed |
| US-20040162240-A1 | Cobalamin conjugates useful as antitumor agents | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2004-08-19 | — | — | US | claimed |
| US-20040063606-A1 | Elastomeric functional biodegradable copolyester amides and copolyester urethanes | CORNELL RESEARCH FOUNDATION, INC. | 2004-04-01 | — | — | US | claimed |
| EP-1313794-A2 | ELASTOMERIC FUNCTIONAL BIODEGRADABLE COPOLYESTER AMIDES AND COPOLYESTER URETHANES | CORNELL RESEARCH FOUNDATION, INC. (US) | 2003-05-28 | — | — | EP | claimed |
| WO-2002086153-A1 | DETERMINING RESISTANCE TO A $G(b)-LACTAM-CONTAINING ANTIBIOTIC BY COMPARING THE RATIO OF TWO $G(b)-LACTAMASE GENES | DIATECH PTY LTD (AU) | 2002-10-31 | — | — | WO | claimed |
| US-20020049155-A1 | Cobalamin compounds useful as cardiovascular agents and as imaging agents | HOGENKAMP HENRICUS P C (US) | 2002-04-25 | — | — | US | claimed |
| US-20020042394-A1 | Cobalamin compounds useful as antibiotic agents and as imaging agents | HOGENKAMP HENRICUS P C (US) | 2002-04-11 | — | — | US | claimed |
| WO-2002018477-A2 | ELASTOMERIC FUNCTIONAL BIODEGRADABLE COPOLYESTER AMIDES AND COPOLYESTER URETHANES | CORNELL RESEARCH FOUNDATION, INC. (US) | 2002-03-07 | — | — | WO | claimed |
| EP-1171162-A2 | COBALAMIN CONJUGATES USEFUL AS ANTITUMOR AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2002-01-16 | — | — | EP | claimed |
| WO-2000062808-A2 | COBALAMIN CONJUGATES USEFUL AS ANTITUMOR AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2000-10-26 | — | — | WO | claimed |
| EP-0326111-A2 | Peptide derivatives rendered immunogenic when administered with alum as an adjuvant | New York Blood Center, Inc. (US) | 1989-08-02 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167270-A1 | ANTI-INFECTIVE PHOSPHONATE ANALOGS | PHOSPHO1, PGLS, PSPH | PTGS1 1631/4885PTGS2 2469/4885SLC7A5 1213/4885 |
| US-20040162240-A1 | Cobalamin conjugates useful as antitumor agents | MMAB, SLC19A2, SLC19A1 | PTGS1 3834/4885PTGS2 3846/4885SLC7A5 32/4885 |
| US-20020049155-A1 | Cobalamin compounds useful as cardiovascular agents and as imaging agents | APOB, MMAB, CBS | PTGS1 2361/4885PTGS2 2299/4885SLC7A5 590/4885 |
| US-20090060837-A1 | COBALAMIN CONJUGATES USEFUL AS ANTITUMOR AGENTS | MMAB, SLC19A2, SLC19A1 | PTGS1 3834/4885PTGS2 3846/4885SLC7A5 32/4885 |
| US-20020042394-A1 | Cobalamin compounds useful as antibiotic agents and as imaging agents | MMAB, BLVRB, AHCY | PTGS1 3135/4885PTGS2 3521/4885SLC7A5 343/4885 |
| US-20040063606-A1 | Elastomeric functional biodegradable copolyester amides and copolyester urethanes | PUF60, UROD, UBE2I | PTGS1 1072/4885PTGS2 1472/4885SLC7A5 1413/4885 |
| US-20080076740-A1 | Antiviral compounds | EIF2AK2, MAVS, ITPA | PTGS1 3229/4885PTGS2 3968/4885SLC7A5 1209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.