Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.62 |
| ▸ | CLK1 | P49759 | 1/20 | 0.61 |
| ▸ | CLK2 | P49760 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.61 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.59 |
| ▸ | KMO | O15229 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.54 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3512029 | 0.90 | AURKA (0.62) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL27116471 | 0.86 | CLK1 (0.66) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL4901590 | 0.83 | ABL1 (0.67) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL27115596 | 0.83 | SYK (0.65) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL3513988 | 0.83 | CAMK2D (0.75) | MTORSMG1MAPK8KMOGSK3B | |
| SCHEMBL2328646 | 0.83 | CLK1 (0.65) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL4892529 | 0.83 | CLK1 (0.65) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL19966813 | 0.83 | ABL1 (0.59) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL6107154 | 0.82 | MTOR (0.55) | AURKACLK1CLK2DYRK1ACLK4 | |
| SCHEMBL15533886 | 0.82 | CLK1 (0.67) | AURKACLK1CLK2DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137309-A1 | FUNGICIDES PHENYL-PYRIMIDNYL-AMINO DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2010-06-03 | — | — | US | claimed |
| CN-101687839-A | Fungicide phenyl-pyrimidinyl-amino derivatives | BAYER CROPSCIENCE SA | 2010-03-31 | — | — | CN | claimed |
| EP-2155713-A1 | FUNGICIDES PHENYL-PYRIMDINYL-AMINO DERIVATIVES | Bayer CropScience SA (FR) | 2010-02-24 | — | — | EP | claimed |
| WO-2008138992-A1 | FUNGICIDES PHENYL-PYRIMDINYL-AMINO DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2008-11-20 | — | — | WO | claimed |
| EP-0672042-B1 | PHARMACOLOGICALLY ACTIVE PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2006-05-03 | — | — | EP | claimed |
| US-5705502-A | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof | NOVARTIS CORPORATION (US) | 1998-01-06 | — | — | US | claimed |
| EP-0672042-A1 | PHARMACOLOGICALLY ACTIVE PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1995-09-20 | — | — | EP | claimed |
| WO-1995009851-A1 | PHARMACOLOGICALLY ACTIVE PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CIBA-GEIGY AG (CH) | 1995-04-13 | — | — | WO | claimed |
| US-20100137309-A1 | FUNGICIDES PHENYL-PYRIMIDNYL-AMINO DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2010-06-03 | — | — | US | disclosed |
| CN-101687839-A | Fungicide phenyl-pyrimidinyl-amino derivatives | BAYER CROPSCIENCE SA | 2010-03-31 | — | — | CN | disclosed |
| EP-2155713-A1 | FUNGICIDES PHENYL-PYRIMDINYL-AMINO DERIVATIVES | Bayer CropScience SA (FR) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138992-A1 | FUNGICIDES PHENYL-PYRIMDINYL-AMINO DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2008-11-20 | — | — | WO | disclosed |
| EP-0672042-B1 | PHARMACOLOGICALLY ACTIVE PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2006-05-03 | — | — | EP | disclosed |
| US-5705502-A | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof | NOVARTIS CORPORATION (US) | 1998-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137309-A1 | FUNGICIDES PHENYL-PYRIMIDNYL-AMINO DERIVATIVES | CYP1A1, CYP1A2, PAH | AURKA 2236/4885CLK1 4490/4885CLK2 4566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.