Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 8/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.69 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.69 |
| ▸ | HRH1 | P35367 | 1/20 | 0.69 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.69 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8237459 | 1.00 | CACNA1I (0.69) | CACNA1IKCNH2CACNA1GCHRM2HRH1 | |
| SCHEMBL3515753 | 0.90 | CACNA1I (0.78) | CACNA1IKCNH2CACNA1GCHRM2HRH1 | |
| SCHEMBL13168100 | 0.90 | CACNA1I (0.78) | CACNA1IKCNH2CACNA1GCHRM2HRH1 | |
| SCHEMBL3515940 | 0.89 | CACNA1I (0.71) | CACNA1IKCNH2CACNA1GCHRM2HRH1 | |
| SCHEMBL13168110 | 0.89 | CACNA1I (0.71) | CACNA1IKCNH2CACNA1GCHRM2HRH1 | |
| SCHEMBL8249505 | 0.89 | KCNH2 (0.82) | CACNA1IKCNH2CACNA1GCHRM2HRH1 | |
| SCHEMBL3513666 | 0.89 | KCNH2 (0.82) | CACNA1IKCNH2CACNA1GCHRM2HRH1 | |
| SCHEMBL8246635 | 0.88 | KCNH2 (0.68) | CACNA1IKCNH2CACNA1GCHRM2HRH1 | |
| SCHEMBL3514721 | 0.87 | KCNH2 (0.67) | CACNA1IKCNH2CACNA1GCHRM2HRH1 | |
| SCHEMBL13168104 | 0.87 | CACNA1I (0.67) | CACNA1IKCNH2CACNA1GCHRM2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222387-A1 | 3-Fluoro-Piperidine T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME CORP. | 2010-09-02 | — | — | US | claimed |
| US-20100222387-A1 | 3-Fluoro-Piperidine T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME CORP. | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222387-A1 | 3-Fluoro-Piperidine T-Type Calcium Channel Antagonists | CACNA1G, CACNA1I, CACNA1H | CACNA1I 2/4885KCNH2 35/4885CACNA1G 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.