Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.82 |
| ▸ | CACNA1I | Q9P0X4 | 7/20 | 0.82 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.82 |
| ▸ | HRH1 | P35367 | 1/20 | 0.82 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.82 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.82 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3513666 | 1.00 | KCNH2 (0.82) | KCNH2CACNA1ICACNA1GCHRM2HRH1 | |
| SCHEMBL3513036 | 0.90 | KCNH2 (1.00) | KCNH2CACNA1ICACNA1GCHRM2HRH1 | |
| SCHEMBL3515947 | 0.90 | KCNH2 (1.00) | KCNH2CACNA1ICACNA1GCHRM2HRH1 | |
| SCHEMBL3516161 | 0.90 | KCNH2 (1.00) | KCNH2CACNA1ICACNA1GCHRM2HRH1 | |
| SCHEMBL3515905 | 0.90 | KCNH2 (1.00) | KCNH2CACNA1ICACNA1GCHRM2HRH1 | |
| SCHEMBL3515940 | 0.89 | CACNA1I (0.71) | KCNH2CACNA1ICACNA1GCHRM2HRH1 | |
| SCHEMBL13168110 | 0.89 | CACNA1I (0.71) | KCNH2CACNA1ICACNA1GCHRM2HRH1 | |
| SCHEMBL3514798 | 0.89 | CACNA1I (0.69) | KCNH2CACNA1ICACNA1GCHRM2HRH1 | |
| SCHEMBL8237459 | 0.89 | CACNA1I (0.69) | KCNH2CACNA1ICACNA1GCHRM2HRH1 | |
| SCHEMBL8246635 | 0.88 | KCNH2 (0.68) | KCNH2CACNA1ICACNA1GCHRM2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222387-A1 | 3-Fluoro-Piperidine T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME CORP. | 2010-09-02 | — | — | US | disclosed |
| US-20100222387-A1 | 3-Fluoro-Piperidine T-Type Calcium Channel Antagonists | MERCK SHARP & DOHME CORP. | 2010-09-02 | — | — | US | disclosed |
| WO-2007002361-A2 | 3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222387-A1 | 3-Fluoro-Piperidine T-Type Calcium Channel Antagonists | CACNA1G, CACNA1I, CACNA1H | KCNH2 35/4885CACNA1I 2/4885CACNA1G 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.