Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8888062 | 0.75 | LTA4H (0.50) | LTA4HMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL20239625 | 0.74 | NR1H2 (0.49) | NR1H2NR1H3ADORA2AADORA1TP53 | |
| SCHEMBL1016030 | 0.73 | MAPK14 (0.53) | NR1H2NR1H3CYP3A4MAPK1KMT2A | |
| SCHEMBL17731014 | 0.72 | AKT2 (0.56) | MAPK1CLK4IKBKEKMT2A | |
| SCHEMBL8036864 | 0.71 | NR1H2 (0.51) | NR1H2NR1H3ADORA2AADORA1MKNK1 | |
| SCHEMBL9787463 | 0.69 | LTB4R (0.49) | NR1H2NR1H3MKNK2CYP3A4TSHR | |
| SCHEMBL31739258 | 0.69 | LTA4H (0.67) | LTB4RLTA4H | |
| SCHEMBL2092574 | 0.69 | LTA4H (0.67) | LTB4RLTA4H | |
| SCHEMBL22636565 | 0.68 | LTA4H (0.49) | ADORA2ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL28717354 | 0.68 | LTA4H (0.49) | LTB4RLTA4HMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324073-A1 | Pyrazolo [1,5-A] Pyrimidine Compounds | WYETH LLC (US) | 2010-12-23 | — | — | US | disclosed |
| US-20100324073-A1 | Pyrazolo [1,5-A] Pyrimidine Compounds | WYETH LLC (US) | 2010-12-23 | — | — | US | disclosed |
| US-20100324073-A1 | Pyrazolo [1,5-A] Pyrimidine Compounds | WYETH LLC (US) | 2010-12-23 | — | — | US | disclosed |
| EP-2235020-A1 | PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS | Wyeth LLC (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009086129-A1 | PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS | WYETH (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009086129-A1 | PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS | WYETH (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324073-A1 | Pyrazolo [1,5-A] Pyrimidine Compounds | NR1H2, NR1H3, NR1H4 | NR1H2 1/4885NR1H3 2/4885ADORA2A 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.