SCHEMBL3515229

SCHEMBL3515229

N#Cc1ccc(CC(c2cnc[nH]2)N2CCN(C(=O)C3(c4ccccc4)CCCC3)CC2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.39
CYP19A1 P11511 2/20 0.39
TRPA1 O75762 1/20 0.39
HSD11B1 P28845 4/20 0.39
SIGMAR1 Q99720 1/20 0.39
CPA1 P15085 1/20 0.38
PIN1 Q13526 4/20 0.37
CNR1 P21554 1/20 0.35
CNR2 P34972 1/20 0.35
GPR55 Q9Y2T6 1/20 0.35
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
TSHR P16473 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
RET P07949 2/20 0.35
MC4R P32245 1/20 0.34
MC5R P33032 1/20 0.34
MC3R P41968 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3517526 0.91 FNTA (0.37) MEN1KMT2ASMN1; SMN2CYP19A1TRPA1
SCHEMBL7555138 0.89 CYP3A4 (0.44) MEN1KMT2ASMN1; SMN2CYP19A1TRPA1
SCHEMBL3518402 0.88 OPRD1 (0.38) SMN1; SMN2TRPA1ALDH1A1LMNATSHR
SCHEMBL3517536 0.87 PIN1 (0.41) CYP19A1CPA1PIN1
SCHEMBL7156162 0.84 CYP19A1 (0.42) CYP19A1CPA1
SCHEMBL3500628 0.80 FNTA (0.54) CYP19A1CPA1
SCHEMBL7560886 0.79 CYP11B1 (0.33) MEN1KMT2ASMN1; SMN2HSD11B1RET
SCHEMBL7188902 0.79 CYP19A1 (0.41) CYP19A1CPA1
SCHEMBL3501778 0.78 CHRM3 (0.46) CYP19A1CPA1
SCHEMBL7121496 0.78 HRH3 (0.36) MEN1KMT2ASMN1; SMN2CYP19A1CPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1744751-A2 METHODS FOR THE TREATMENT OF SYNUCLEINOPATHIES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2007-01-24 EP claimed
WO-2005089502-A2 METHODS FOR THE TREATMENT OF SYNUCLEINOPATHIES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2005-09-29 WO claimed
WO-2000059930-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 2000-10-12 WO claimed
EP-2155197-A2 TREATMENT OF LYSOSOMAL STORAGE DISEASES Link Medicine Corporation (US) 2010-02-24 EP disclosed
WO-2008112525-A2 TREATMENT OF LYSOSOMAL STORAGE DISEASES LINK MEDICINE CORPORATION (US) 2008-09-18 WO disclosed