Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 11/20 | 0.47 |
| ▸ | NPY1R | P25929 | 6/20 | 0.47 |
| ▸ | NPY2R | P49146 | 4/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.47 |
| ▸ | FURIN | P09958 | 5/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | PCSK6 | P29122 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2407969 | 0.90 | NPY4R (0.45) | NPY4RNPY1RNPY2RNPY5RGNAI3 | |
| SCHEMBL30486089 | 0.88 | NPY4R (0.49) | NPY4RNPY1RNPY2RNPY5RFURIN | |
| SCHEMBL4331923 | 0.86 | NPY4R (0.44) | NPY4RNPY1RNPY2RNPY5RGNAI3 | |
| SCHEMBL30844259 | 0.86 | NPY4R (0.48) | NPY4RNPY1RNPY2RNPY5RFURIN | |
| SCHEMBL30486088 | 0.86 | NPY4R (0.46) | NPY4RNPY1RNPY2RNPY5RFURIN | |
| SCHEMBL8742594 | 0.86 | NPY4R (0.51) | NPY4RNPY1RNPY2RNPY5RFURIN | |
| SCHEMBL31376472 | 0.86 | NPY4R (0.51) | NPY4RNPY1RNPY2RNPY5RFURIN | |
| SCHEMBL30423395 | 0.86 | NPY4R (0.51) | NPY4RNPY1RNPY2RNPY5RFURIN | |
| SCHEMBL29378646 | 0.86 | NPY4R (0.51) | NPY4RNPY1RNPY2RNPY5RFURIN | |
| SCHEMBL30121066 | 0.86 | NPY4R (0.51) | NPY4RNPY1RNPY2RNPY5RFURIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155894-A2 | TARGETING HOST PROTEINASES AS A THERAPEUTIC STRATEGY AGAINST VIRAL AND BACTERIAL PATHOGENS | Burnham Institute for Medical Research (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2009023306-A2 | TARGETING HOST PROTEINASES AS A THERAPEUTIC STRATEGY AGAINST VIRAL AND BACTERIAL PATHOGENS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-02-19 | — | — | WO | disclosed |
| EP-1663300-A1 | INHIBITORS OF PACE4 FOR THE TREATMENT OF ARTHRITIS | Pharmacia Corporation (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005025611-A1 | INHIBITORS OF PACE4 FOR THE TREATMENT OF ARTHRITIS | PHARMACIA CORPORATION (US) | 2005-03-24 | — | — | WO | disclosed |