Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.76 |
| ▸ | DKK1 | O94907 | 2/20 | 0.76 |
| ▸ | GSK3B | P49841 | 2/20 | 0.76 |
| ▸ | CDK2 | P24941 | 5/20 | 0.65 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.65 |
| ▸ | CDK1 | P06493 | 4/20 | 0.65 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.65 |
| ▸ | CDK9 | P50750 | 4/20 | 0.65 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.65 |
| ▸ | CDK7 | P50613 | 3/20 | 0.65 |
| ▸ | CCNH | P51946 | 3/20 | 0.65 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.65 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3520377 | 0.86 | IKBKB (0.60) | IKBKBDKK1GSK3BCDK2CCNT1 | |
| SCHEMBL3520298 | 0.85 | IKBKB (0.76) | IKBKBDKK1GSK3BCDK2CCNT1 | |
| SCHEMBL3517546 | 0.83 | IKBKB (0.73) | IKBKBDKK1GSK3BCDK2CCNT1 | |
| SCHEMBL13051459 | 0.83 | IKBKB (0.56) | IKBKBDKK1GSK3BCDK2CCNT1 | |
| SCHEMBL3518369 | 0.82 | IKBKB (0.71) | IKBKBDKK1GSK3BCDK2CCNT1 | |
| SCHEMBL3519328 | 0.82 | IKBKB (0.91) | IKBKBDKK1GSK3BCDK2CCNT1 | |
| SCHEMBL3516379 | 0.82 | IKBKB (0.71) | IKBKBDKK1GSK3BCDK2CCNT1 | |
| SCHEMBL12423196 | 0.82 | IKBKB (0.65) | IKBKBDKK1GSK3BCDK2CCNT1 | |
| SCHEMBL12423171 | 0.81 | IKBKB (0.55) | IKBKBDKK1GSK3BCDK2CCNT1 | |
| SCHEMBL12423166 | 0.81 | SYK (0.58) | IKBKBDKK1GSK3BCDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | claimed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | claimed |
| US-7799915-B2 | Anilino-pyrimidine analogs | WYETH LLC (US) | 2010-09-21 | — | — | US | disclosed |
| CN-101460491-A | Anilino-pyrimidine phenyl and benzothiophene analogs | WYETH CORP (US) | 2009-06-17 | — | — | CN | disclosed |
| EP-2004638-A1 | ANILINO-PYRIMIDINE PHENYL AND BENZOTHIOPHENE ANALOGS | Wyeth a Corporation of the State of Delaware (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120593-A1 | ANILINO-PYRIMIDINE PHENYL AND BENZOTHIOPHENE ANALOGS | WYETH (US) | 2007-10-25 | — | — | WO | disclosed |
| US-20070244140-A1 | Anilino-pyrimidine phenyl and benzothiophene analogs | WYETH (US) | 2007-10-18 | — | — | US | disclosed |
| CN-101039919-A | N-benzenesulfonyl substituted anilino-pyrimidine analogs | WYETH CORP (US) | 2007-09-19 | — | — | CN | disclosed |
| EP-1799652-A1 | N-BENZENESULFONYL SUBSTITUTED ANILINO-PYRIMIDINE ANALOGS | Wyeth (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006044457-A1 | N-BENZENESULFONYL SUBSTITUTED ANILINO-PYRIMIDINE ANALOGS | WYETH (US) | 2006-04-27 | — | — | WO | disclosed |
| US-20060079543-A1 | Anilino-pyrimidine analogs | WYETH (US) | 2006-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244140-A1 | Anilino-pyrimidine phenyl and benzothiophene analogs | HPRT1, APRT, NUDT1 | IKBKB 3482/4885DKK1 2698/4885GSK3B 1720/4885 |
| US-20060079543-A1 | Anilino-pyrimidine analogs | DPYD, TYMP, ADORA3 | IKBKB 3246/4885DKK1 2975/4885GSK3B 2108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.