SCHEMBL3516564

SCHEMBL3516564

Nc1nc2cc(-c3cccnc3)ccc2c2[nH]cnc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
QPCT Q16769 1/20 0.50
QPCTL Q9NXS2 1/20 0.50
DHFR P00374 2/20 0.46
LIMK1 P53667 2/20 0.45
PIK3CA P42336 2/20 0.42
PIK3CD O00329 1/20 0.42
PIP5K1C O60331 1/20 0.42
PI4KA P42356 1/20 0.42
PI4KB Q9UBF8 1/20 0.42
MEN1 O00255 1/20 0.41
PSIP1 O75475 1/20 0.41
AXL P30530 1/20 0.41
MKNK1 Q9BUB5 1/20 0.41
MKNK2 Q9HBH9 1/20 0.41
CYP11B1 P15538 3/20 0.41
CYP11B2 P19099 3/20 0.41
CYP19A1 P11511 2/20 0.41
CYP17A1 P05093 1/20 0.40
FGFR1 P11362 2/20 0.40
AURKA O14965 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3352424 0.77 KDM4C (0.45) GSK3BCDK5DYRK1ATBK1
SCHEMBL29736922 0.77 LIMK1 (0.44) DHFRLIMK1PIK3CAFYN
SCHEMBL483673 0.76 ATR (0.41) QPCTQPCTLPIK3CAMEN1PSIP1
SCHEMBL30074868 0.75 PDPK1 (0.33) DHFRMEN1AURKAAURKBCHEK1
SCHEMBL4378158 0.74 CLK1 (0.40) PI4KAPI4KBJAK2GSK3BCDK5
Hydrochloric Acid SCHEMBL30842203 0.74 PDPK1 (0.33) DHFRMEN1AURKAAURKBCHEK1
Hydrochloric Acid SCHEMBL30324815 0.74 PDPK1 (0.33) DHFRMEN1AURKAAURKBCHEK1
SCHEMBL20943829 0.74 NLRP3 (0.41) DHFRLIMK1PIK3CAPIK3CDPIP5K1C
SCHEMBL2113965 0.73 PTGES (0.44) MEN1CHEK1JAK2PIM1PRKACA
SCHEMBL21949805 0.73 NLRP3 (0.59) DHFRLIMK1PIK3CAPIK3CDPIP5K1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250152703-A1 COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2025-05-15 US disclosed
US-12201684-B2 Compositions for stimulation of mammalian innate immune resistance to pathogens THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-01-21 US disclosed
US-20240417738-A1 IMMUNOTHERAPIES FOR THE TREATMENT OF CANCER OHIO STATE INNOVATION FOUNDATION 2024-12-19 US disclosed
EP-4419112-A1 IMMUNOTHERAPIES FOR THE TREATMENT OF CANCER Ohio State Innovation Foundation (US) 2024-08-28 EP disclosed
US-20240033348-A1 METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATION Pulmotect, Inc. 2024-02-01 US disclosed
US-11826422-B2 Methods and compositions for adaptive immune modulation BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-11-28 US disclosed
WO-2023070132-A1 IMMUNOTHERAPIES FOR THE TREATMENT OF CANCER OHIO STATE INNOVATION FOUNDATION (US) 2023-04-27 WO disclosed
US-8709445-B2 Vaccination with killed but metabolically active (KBMA) protozoans with toll-like receptor agonists LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) 2014-04-29 US disclosed
US-20100310606-A1 VACCINATION WITH KILLED BUT METABOLICALLY ACTIVE (KBMA) PROTOZOANS WITH TOLL-LIKE RECEPTOR AGONISTS LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) 2010-12-09 US disclosed